Title: Medronic Acid
CAS Registry Number: 1984-15-2
CAS Name: Methylenebisphosphonic acid
Synonyms: methylenediphosphonic acid; methanebisphosphonic acid; methanediphosphonic acid; MDP
Molecular Formula: CH6O6P2
Molecular Weight: 176.00
Percent Composition: C 6.82%, H 3.44%, O 54.54%, P 35.20%
Literature References: Prepn: G. Schwarzenbach, J. Zurc,
Monatsh. Chem. 81, 202 (1950),
C.A. 44, 8205f (1950); V. A. Ginsburg, A. Y. Yakubovich,
J. Gen. Chem. USSR 28, 710 (1958),
C.A. 52, 17091g (1958); J. A. Cade,
J. Chem. Soc. 1959, 2266. Physical properties: K. Moedritzer, R. R. Irani,
J. Inorg. Nucl. Chem. 22, 297 (1961). Prepn of 99mTc-complexes: G. Subramanian, J. G. McAfee,
US 4032625 (1977 to Research Corp.); J. Kroesbergen
et al., Int. J. Nucl. Med. Biol. 12, 419 (1986). HPLC separation of 99mTc-complexes: D. J. Hoch, T. C. Pinkerton,
Appl. Radiat. Isot. 37, 593 (1986). Biodistribution, toxicity and clinical evaluation for skeletal imaging: G. Subramanian
et al., J. Nucl. Med. 16, 744 (1975). Comparative biodistribution studies: G. Subramanian
et al., Radiology 149, 823 (1983). Clinical pharmacokinetics: L. Rosenthall
et al., Clin. Nucl. Med. 2, 232 (1977). Clinical studies for bone imaging: U. Büll
et al., Br. J. Radiol. 50, 629 (1977); for neuroblastoma imaging: I. Garty
et al., Clin. Nucl. Med. 14, 515 (1989).
Properties: Crystals from acetic acid, mp 199-200°. LD50 in mice, rabbits (mg/kg): 45-50 i.v. (Subramanian, 1975).
Melting point: mp 199-200°
Toxicity data: LD50 in mice, rabbits (mg/kg): 45-50 i.v. (Subramanian, 1975)
Derivative Type: 99mTc-Complex
Synonyms: 99mTc-MDP
Trademarks: Amerscan MDP (Amersham); Osteolite (DuPont); TechneScan MDP (Mallinckrodt)
Therap-Cat: 99mTc complex as diagnostic aid (radioactive imaging agent).
