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CAS No 19387-91-8 , 1-(2-ethylsulfonylethyl)-2-methyl-5-nitroimidazole Search by region : Germany

  • Name: 1-(2-ethylsulfonylethyl)-2-methyl-5-nitroimidazole
  • Synonyms: Tindamax;1-(2-ethylsulfonylethyl)-2-methyl-5-nitroimidazole; Tinidazolum; Tricolam;Fasigyn; 19387-91-8; Simplotan; Tinidazol; Fasigin; Bioshik;
  • CAS Registry Number:
  • Melting Point: 125ºCto 128ºC
  • Flash Point: 273.4ºC
  • Boiling Point: 528.4ºC at 760 mmHg
  • Density: 1.43 g/cm3
  • Refractive index: 1.599
  • Safety Statements: R20/21/22;R40
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 273.4ºC
  • EINECS: 243-014-4
  • Molecular Weight: 247.27152
  • InchiKey: HJLSLZFTEKNLFI-UHFFFAOYSA-N
  • InChI: InChI=1S/C8H13N3O4S/c1-3-16(14,15)5-4-10-7(2)9-6-8(10)11(12)13/h6H,
    3-5H2,1-2H3
  • Risk Statements: S26;S36
  • Molecular Formula: C8H13N3O4S
  • Molecular Structure:CAS No:19387-91-8 1-(2-ethylsulfonylethyl)-2-methyl-5-nitroimidazole

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19387-91-8 TINIDAZOLE

  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany null,nullGermany
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References of 1-(2-ethylsulfonylethyl)-2-methyl-5-nitroimidazole
Title: Tinidazole
CAS Registry Number: 19387-91-8
CAS Name: 1-[2-(Ethylsulfonyl)ethyl]-2-methyl-5-nitro-1H-imidazole
Synonyms: ethyl[2-(2-methyl-5-nitro-1-imidazolyl)ethyl]sulfone
Manufacturers' Codes: CP-12574
Trademarks: Fasigin (Pfizer); Fasigyn (Pfizer); Simplotan (Pfizer); Tindamax (Presutti); Tricolam (Pfizer); Trimonase (Mipharm)
Molecular Formula: C8H13N3O4S
Molecular Weight: 247.27
Percent Composition: C 38.86%, H 5.30%, N 16.99%, O 25.88%, S 12.97%
Literature References: Prepn: K. Butler, US 3376311 (1968 to Pfizer); M. W. Miller et al., J. Med. Chem. 13, 849 (1970). Series of articles on prepn, antiprotozoal activity and pharmacokinetics: Antimicrob. Agents Chemother. 1969, 257-270. Review of antiprotozoal activity: P. R. Sawyer et al., Drugs 11, 423-440 (1976); of antibacterial activity, pharmacology and therapeutic efficacy vs anaerobes: A. A. Carmine et al., ibid. 24, 85-117 (1982). Symposium on clinical experience in anaerobic infection: J. Antimicrob. Chemother. 10, Suppl. A, 1-184 (1982). Clinical trial in Helicobacter pylori positive gastritis: G. Oderda et al., Gut 33, 1328 (1992).
Properties: Colorless crystals from benzene, mp 127-128°. LD50 in mice (mg/kg): >3600 orally; >2000 i.p. (Miller).
Melting point: mp 127-128°
Toxicity data: LD50 in mice (mg/kg): >3600 orally; >2000 i.p. (Miller)
Therap-Cat: Antiprotozoal (Trichomonas, Giardia); antiamebic; antibacterial.
Keywords: Antiamebic; Antiprotozoal (Giardia); Antiprotozoal (Trichomonas).