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CAS No 191732-72-6 , 3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione

  • Name: 3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
  • Synonyms: CC-5013; CC 5013; IMiD3; CDC-501; Revimid; Revlimid (Celgene); 191732-72-6;3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione;Revlimid; CDC 501;
  • CAS Registry Number:
  • Density: 1.46g/cm3
  • Refractive index: 1.672
  • Molecular Weight: 259.26062
  • InchiKey: GOTYRUGSSMKFNF-UHFFFAOYSA-N
  • InChI: InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12
    (10)18/h1-3,10H,4-6,14H2,(H,15,17,18)
  • Molecular Formula: C13H13N3O3
  • Molecular Structure:CAS No:191732-72-6 3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione

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References of 3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
Title: Lenalidomide
CAS Registry Number: 191732-72-6
CAS Name: 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
Synonyms: 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline
Manufacturers' Codes: CC-5013
Trademarks: Revimid (Celgene); Revlimid (Celgene)
Molecular Formula: C13H13N3O3
Molecular Weight: 259.26
Percent Composition: C 60.22%, H 5.05%, N 16.21%, O 18.51%
Literature References: Immunomodulatory drug; analog of thalidomide, q.v. Prepn: G. W. Muller et al., US 5635517 (1997 to Celgene); and in vitro TNF-a inhibition: eidem, Bioorg. Med. Chem. Lett. 9, 1625 (1999). LC-MS determn in plasma: T. M. Tohnya et al., J. Chromatogr. B 811, 135 (2004). Clinical evaluation in multiple myeloma: P. G. Richardson et al., Blood 100, 3063 (2002); in myelodysplastic syndromes: A. List et al., N. Engl. J. Med. 352, 549 (2005). Review of development, pharmacology and therapeutic potential: J. B. Bartlett et al., Nature Rev. 4, 314-322 (2004); C. S. Mitsiades, N. Mitsiades, Curr. Opin. Invest. Drugs 5, 635-647 (2004).
Therap-Cat: Immunomodulator.
Keywords: Immunomodulator.