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CAS No 19171-19-8 , 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

  • Name: 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
  • Synonyms: Actimid; CC 4047; 4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione; 4-Aminothalidomide; CHEBI:72690; CC-4047; 19171-19-8;4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; Pomalyst;
  • CAS Registry Number:
  • Flash Point: 306.3°C
  • Boiling Point: 582.9°Cat760mmHg
  • Density: 1.57g/cm3
  • Refractive index: 1.691
  • Flash Point: 306.3°C
  • Molecular Weight: 273.24414
  • InchiKey: UVSMNLNDYGZFPF-UHFFFAOYSA-N
  • InChI: InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11
    (8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
  • Molecular Formula: C13H11N3O4
  • Molecular Structure:CAS No:19171-19-8 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

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19171-19-8 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

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References of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Title: Actimid (Celgene)
CAS Registry Number: 19171-19-8
CAS Name: 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Synonyms: 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide; 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline
Manufacturers' Codes: CC-4047
Molecular Formula: C13H11N3O4
Molecular Weight: 273.24
Percent Composition: C 57.14%, H 4.06%, N 15.38%, O 23.42%
Literature References: Second generation immunomodulator and TNF-a inhibitor; analog of thalidomide, q.v. Prepn: G. W. Muller et al., WO 9803502; eidem, US 6335349 (1998, 2002 both to Celgene); eidem, Bioorg. Med. Chem. Lett. 9, 1625 (1999). In vivo immunostimulant activity in cancer vaccine model: K. Dredge et al., J. Immunol. 168, 4914 (2002). Mechanism of action study: F. Payvandi et al., Cell. Immunol. 230, 81 (2004). In vitro immunodulation of hematopoietic stem cells: K.-R. Koh et al., Blood 105, 3833 (2005). Clinical pharmacokinetics and clinical evaluation in multiple myeloma: S. A. Schey et al., J. Clin. Oncol. 22, 3269 (2004).
Properties: Yellow solid from dioxane + ethyl acetate, mp 318.5 - 320.5°.
Melting point: mp 318.5 - 320.5°
Therap-Cat: Immunomodulator.
Keywords: Immunomodulator.