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CAS No 18883-66-4 , Streptozocin

  • Name: Streptozocin
  • Synonyms: 2-desoxy-2-(3-methyl-3-nitrosoureido)-d-glucopyranose; Streptozotocin; 2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)-d-glucose;Streptozocin; 2-Deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose;2-Desoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose;
  • CAS Registry Number:
  • Transport: OTH
  • Melting Point: 115 ºC (DEC.)
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.86 g/cm3
  • Refractive index: 1.67
  • Safety Statements: R22;R45;R46;R61
  • Hazard Symbols: T: Toxic;
  • Flash Point: °C
  • EINECS: 242-646-8
  • Molecular Weight: 265.22
  • InChI: InChI=1/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1
  • Risk Statements: S45;S53
  • Molecular Formula: C8H15N3O7
  • Molecular Structure:CAS No:18883-66-4 Streptozocin

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18883-66-4 Streptozocin

  • "Appearance Pale yellow crystalline powder Assay,HPLC 98.5-101.5% Solubility Soluble in water Identification UV: the UV absorption of 0.001% solution in water exhibits a max at about 228nm IR:IR Spectrum in potassium bromide dispersion of sample shou...
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References of Streptozocin
Title: Streptozocin
CAS Registry Number: 18883-66-4
CAS Name: 2-Deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucopyranose
Synonyms: 2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; streptozotocin
Manufacturers' Codes: NSC-85998; U-9889
Trademarks: Zanosar (Pharmacia & Upjohn)
Molecular Formula: C8H15N3O7
Molecular Weight: 265.22
Percent Composition: C 36.23%, H 5.70%, N 15.84%, O 42.23%
Literature References: Isoln from Streptomyces achromogenes fermentation broth: Herr et al., Antibiot. Annu. 1959-1960, 236; Bergy et al., FR 1434920 (1966 to Upjohn), C.A. 65, 17661h (1966). Structure and synthesis: Herr et al., J. Am. Chem. Soc. 89, 4808 (1967); Hardegger et al., Helv. Chim. Acta 52, 2555 (1969); Hessler, Jahnke, J. Org. Chem. 35, 245 (1970); P. F. Wiley et al., ibid. 44, 9 (1979). Diabetogenic effect: Rakieten et al., Cancer Chemother. Rep. 29, 91 (May 1963). Comparison of streptozotocin- and alloxan-induced diabetes: C. Rerup, F. Tarding, Eur. J. Clin. Pharmacol. 7, 89 (1969). Antileukemic activity: Bhuyan et al., Cancer Chemother. Rep. Part 1 56, 709 (1972). Biosynthetic study: S. Singaram et al., J. Antibiot. 32, 379 (1979). Review and evaluation of studies of carcinogenicity in laboratory animals: IARC Monographs 4, 221-227 (1974). Toxicity data: M. Iwasaki et al., J. Med. Chem. 19, 918 (1976). Review: B. Rudas, Arzneim.-Forsch. 22, 830-861 (1972); P. F. Wiley, Anticancer Agents Based on Natural Product Models, J. M. Cassidy, J. D. Douros, Eds. (Academic Press, New York, 1980) pp 167-200. Book: Streptozotocin: Fundamentals and Therapy, M. K. Agarwal, Ed. (Elsevier/North Holland Biomedical Press, New York, 1981) 309 pp.
Properties: Pointed platelets or prisms, from 95% ethanol, mp 115° (dec). Sol in H2O, lower alcohols and ketones. uv max (ethanol): 228 nm (e 6360). A mixture of a and b anomers; aq solns rapidly undergo mutarotation to an equilibrium value of [a]D25 +39°. LD50 in female mice (mg/kg): 360 i.p.; 275 i.v.; in male dogs (mg/kg): 50 i.v. (Iwasaki).
Melting point: mp 115° (dec)
Optical Rotation: [a]D25 +39°
Absorption maximum: uv max (ethanol): 228 nm (e 6360)
Toxicity data: LD50 in female mice (mg/kg): 360 i.p.; 275 i.v.; in male dogs (mg/kg): 50 i.v. (Iwasaki)
 
Derivative Type: Tetraacetate
Molecular Formula: C8H11N3O7(COCH3)4
Molecular Weight: 433.37
Percent Composition: C 44.34%, H 5.35%, N 9.70%, O 40.61%
Properties: Crystals, mp 111-114° (dec). [a]D25 +41° (c = 0.78 in 95% ethanol).
Melting point: mp 111-114° (dec)
Optical Rotation: [a]D25 +41° (c = 0.78 in 95% ethanol)
 
CAUTION: Streptozocin is reasonably anticipated to be a human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-234.
Use: Production of experimental diabetes in laboratory animals.
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Antibiotics and Analogs.