Home > Name List By n > N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy) quinazolin-4-amine

CAS No 184475-35-2 , N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)
quinazolin-4-amine

  • Name: N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)
    quinazolin-4-amine
  • Synonyms: Gefitinib [USAN];Iressa; ZD-1839; 184475-35-2; Iressa (TN); ZD1839; Irressat;N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)
    quinazolin-4-amine; Iressa(TM); ZD 1839;
  • CAS Registry Number:
  • Melting Point: 119-120
  • Density: 1.322g/cm3
  • Refractive index: 1.621
  • Molecular Weight: 446.902363
  • InchiKey: XGALLCVXEZPNRQ-UHFFFAOYSA-N
  • InChI: InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-
    7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,
    1H3,(H,25,26,27)
  • Molecular Formula: C22H24ClFN4O3
  • Molecular Structure:CAS No:184475-35-2 N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)<br />quinazolin-4-amine

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References of N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)
quinazolin-4-amine
Title: Gefitinib
CAS Registry Number: 184475-35-2
CAS Name: N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine
Synonyms: 4-(3￠-chloro-4￠-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline
Manufacturers' Codes: ZD-1839
Trademarks: Iressa (AstraZeneca)
Molecular Formula: C22H24ClFN4O3
Molecular Weight: 446.90
Percent Composition: C 59.13%, H 5.41%, Cl 7.93%, F 4.25%, N 12.54%, O 10.74%
Literature References: Selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor which blocks signal transduction pathways implicated in the proliferation and survival of cancer cells. Prepn: K. H. Gibson, WO 9633980; idem, US 5770599 (1996, 1998 both to Zeneca). LC/MS/MS determn in biological samples: M. Zhao et al., J. Chromatogr. B 819, 73 (2005). Clinical pharmacokinetics and tolerability: H. Swaisland et al., Clin. Pharmacokinet. 40, 297 (2001). In vitro and in vivo inhibition of EGFR-expressing cancer lines: N. G. Anderson et al., Int. J. Cancer 94, 774 (2001). Proposed mechanism of action: A. Hirata et al., Cancer Res. 62, 2554 (2002). Clinical study in non-small cell lung cancer: M. G. Kris et al., J. Am. Med. Assoc. 290, 2149 (2003). Review: C. L. Arteaga, D. H. Johnson, Curr. Opin. Oncol. 13, 491-498 (2001). Review of clinical evaluations: D. Raben et al., Semin. Oncol. 29, Suppl. 4, 37-46 (2002); of use in non-small cell lung cancer: K. Tamura, M. Fukuoka, Expert Opin. Pharmacother. 6, 985-993 (2005).
Properties: Crystals from toluene, mp 119-120°.
Melting point: mp 119-120°
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Tyrosine Kinase Inhibitors.