Home > Name List By n > N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy) quinazolin-4-amine

CAS No 184475-35-2 , N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)
quinazolin-4-amine

  • Name: N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)
    quinazolin-4-amine
  • Synonyms: Gefitinib [USAN];Iressa; ZD-1839; 184475-35-2; Iressa (TN); ZD1839; Irressat;N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)
    quinazolin-4-amine; Iressa(TM); ZD 1839;
  • CAS Registry Number:
  • Melting Point: 119-120
  • Density: 1.322g/cm3
  • Refractive index: 1.621
  • Molecular Weight: 446.902363
  • InchiKey: XGALLCVXEZPNRQ-UHFFFAOYSA-N
  • InChI: InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-
    7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,
    1H3,(H,25,26,27)
  • Molecular Formula: C22H24ClFN4O3
  • Molecular Structure:CAS No:184475-35-2 N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)<br />quinazolin-4-amine
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184475-35-2 Gefitinib

  • Gefitinib Synonyms:Iressa;Gefitinib;Akos 91371;N-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine;N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine;Zd 1839;4-quinazolinamine, n-(3-c...
  • Min. Order: 1000
  • FOB Price: USD1 - 2 /
  • China Hubei Yuancheng Saichuang Technology Co.,Ltd. [Manufacturer]
  • Tel: 86-27-50756228
  • Fax: 86-27-88048077
  • Address: Wuchang wuhan,HubeiChina
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184475-35-2 Top quality of Gefitinib(CAS:184475-35-2)

  • Top quality of Gefitinib(CAS:184475-35-2) Email:dahuamanager@whdhwy.com Skype:selenayang07 Whatsapp:+8615623826482 Synonyms:Irressat;Gefitinib (JAN/USAN);4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]- CAS:18447...
  • Min. Order: 10000
  • China Wuhan Dahua Weiye Pharmaceutical Co.,Ltd [Manufacturer]
  • Tel: 86-27-59848232
  • Fax: 86-27-59420980
  • Address: No. 45 Daijiangshan Jiangan District, Wuhan, Hubei, China Wuhan,HubeiChina
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184475-35-2 Iressa

  • China Hangzhou Sage Chemical Co., Ltd. [Manufacturer]
  • Tel: +86-571-86818502
  • Fax: +86-571-86818503
  • Address: RM501 Tower A, New Youth Plaza, NO.8 Jia Shan Road, Hangzhou, Zhejiang 310014, null,ZhejiangChina
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184475-35-2 Gefitinib

  • cas:184475-35-2 Gefitinib Antineoplastic Agents
  • China Jinan Jinghai Chemical Co.,Ltd. [Manufacturer, Trading Company]
  • Tel: 86-0831-88910015
  • Fax: --
  • Address: No.81,Xin Zhu Rd. Jinan,ShandongChina

184475-35-2 Iressa

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184475-35-2 Iressa

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
  • Fax: +86-351-7436719
  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi null,ShanXiChina
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184475-35-2 Gefitinib

  • Product Gefitinib and Intermediates CAS NO 184475-35-2 Standard Enterprise Standard Molecular Formula C22H24ClFN4O3 Molecular Weight 446.9 Description white crystal or crystalline powder Package 25KG/drums Application anticancer
  • China Jinan Jianfeng Chemical Co.Ltd [Manufacturer]
  • Tel: 86-531-88110457
  • Fax: --
  • Address: NO9. Hua Neng Road, Jinan, China Jinan,ShandongChina

184475-35-2 Iressa

  • China Shanghai Jinglan Chemical Co., Ltd. [Manufacturer]
  • Tel: 86-21-37789410
  • Fax: 86-21-64966973
  • Address: Room 513, 5th Floor, Building B,
    No. 18, Lane 1305, Huajing Road,
    Shanghai, 200231, P.R. China null,nullChina
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184475-35-2 Iressa

  • China XinChem Corporation [Manufacturers]
  • Tel: +86-(21)-34123252
  • Fax: +86-(21)-54153973
  • Address: 102/30, 3455 Chunshen Road, Shanghai 201100, null,ShanghaiChina
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184475-35-2 Gefitinib

  • Germany Fox Chemicals GmbH [Manufacturer]
  • Tel: +49.7240.927151/ +49.160.95781845 (Mobile)
  • Fax: +49.7240.927150
  • Address: Fox Chemicals GmbH
    Bockstalstr.10 A
    D-76327 Pfinztal-Germany null,nullGermany
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References of N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)
quinazolin-4-amine
Title: Gefitinib
CAS Registry Number: 184475-35-2
CAS Name: N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine
Synonyms: 4-(3¢-chloro-4¢-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline
Manufacturers' Codes: ZD-1839
Trademarks: Iressa (AstraZeneca)
Molecular Formula: C22H24ClFN4O3
Molecular Weight: 446.90
Percent Composition: C 59.13%, H 5.41%, Cl 7.93%, F 4.25%, N 12.54%, O 10.74%
Literature References: Selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor which blocks signal transduction pathways implicated in the proliferation and survival of cancer cells. Prepn: K. H. Gibson, WO 9633980; idem, US 5770599 (1996, 1998 both to Zeneca). LC/MS/MS determn in biological samples: M. Zhao et al., J. Chromatogr. B 819, 73 (2005). Clinical pharmacokinetics and tolerability: H. Swaisland et al., Clin. Pharmacokinet. 40, 297 (2001). In vitro and in vivo inhibition of EGFR-expressing cancer lines: N. G. Anderson et al., Int. J. Cancer 94, 774 (2001). Proposed mechanism of action: A. Hirata et al., Cancer Res. 62, 2554 (2002). Clinical study in non-small cell lung cancer: M. G. Kris et al., J. Am. Med. Assoc. 290, 2149 (2003). Review: C. L. Arteaga, D. H. Johnson, Curr. Opin. Oncol. 13, 491-498 (2001). Review of clinical evaluations: D. Raben et al., Semin. Oncol. 29, Suppl. 4, 37-46 (2002); of use in non-small cell lung cancer: K. Tamura, M. Fukuoka, Expert Opin. Pharmacother. 6, 985-993 (2005).
Properties: Crystals from toluene, mp 119-120°.
Melting point: mp 119-120°
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Tyrosine Kinase Inhibitors.