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CAS No 17692-51-2 , Carbamic acid, N-[[(8b)-1,6-dimethylergolin-8-yl]methyl]-,phenylmethyl ester

  • Name: Carbamic acid, N-[[(8b)-1,6-dimethylergolin-8-yl]methyl]-,phenylmethyl ester
  • Synonyms: FI 6337;D-8b-[(Carbobenzoxyamino)methyl]-1,6-dimethyl-10a-ergoline; D-8b-[(Carboxyamino)methyl]-1,6-dimethylergolineI benzyl ester; MCE; 8b-Carbobenzyloxyaminomethyl-1,6-dimethyl-10a-ergoline; Carbamic acid, [[(8b)-1,6-dimethylergolin-8-yl]methyl]-,phenylmethyl ester (9CI); Methergoline; AHR 3009; Ergoline, carbamic acid deriv.;Carbamic acid, N-[[(8b)-1,6-dimethylergolin-8-yl]methyl]-,phenylmethyl ester; Metergoline;D-[(4,6,6a,7,8,9,10,10a-Octahydro-4,7-dimethyl-10aa-indolo[4,3-fg]quinolin-9b-yl)methyl]carbamic acid benzyl ester; Indolo[4,3-fg]quinoline, carbamicacid deriv.;D-N-Carboxydihydro-1-methyllysergamine I benzyl ester; Contralac; Lysergamine, N-carboxy-9,10-dihydro-1-methyl-, benzylester (7CI);Liserdol; Metergolin; D-N-Carbobenzoxydihydro-1-methyllysergamine I;Carbamicacid, [(1,6-dimethylergolin-8b-yl)methyl]-, benzyl ester (8CI); (+)-N-Carboxy-1-methyl-9,10-dihydrolysergamide benzyl ester;
  • CAS Registry Number:
  • Melting Point: 148-150 °C(lit.)
  • Flash Point: 324.2°C
  • Boiling Point: 612.5°Cat760mmHg
  • Density: 1.25g/cm3
  • Safety Statements: Hazard Codes XnRisk Statements 20/21/22Safety Statements 36WGK Germany 3 RTECS FA1070000
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 324.2°C
  • EINECS: 241-686-3
  • Molecular Weight: 403.52
  • InChI: InChI=1S/C25H29N3O2/c1-27-14-18(13-26-25(29)30-16-17-7-4-3-5-8-17)11-21-20-9-6-10-22-24(20)19(12-23(21)27)15-28(22)2/h3-10,15,18,21,23H,11-14,16H2,1-2H3,(H,26,29)/t18-,21?,23?/m1/s1
  • Risk Statements: 20/21/22
  • Molecular Formula: C25H29N3O2
  • Molecular Structure:CAS No:17692-51-2 Carbamic acid, N-[[(8b)-1,6-dimethylergolin-8-yl]methyl]-,phenylmethyl ester

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References of Carbamic acid, N-[[(8b)-1,6-dimethylergolin-8-yl]methyl]-,phenylmethyl ester
Title: Metergoline
CAS Registry Number: 17692-51-2
CAS Name: [[(8b)-1,6-Dimethylergolin-8-yl]methyl]carbamic acid phenylmethyl ester
Synonyms: D-8b-[(carbobenzoxyamino)methyl]-1,6-dimethyl-10a-ergoline; D-N-carbobenzoxydihydro-1-methyllysergamine I; D-8b-[(carboxyamino)methyl]-1,6-dimethylergoline I benzyl ester; D-N-carboxydihydro-1-methyllysergamine I benzyl ester; D-[(4,6,6a,7,8,9,10,10a-octahydro-4,7-dimethyl-10aa-indolo[4,3-fg]quinolin-9b-yl)methyl]carbamic acid benzyl ester; methergoline
Trademarks: Liserdol (Farmitalia); Contralac (Virbac)
Molecular Formula: C25H29N3O2
Molecular Weight: 403.52
Percent Composition: C 74.41%, H 7.24%, N 10.41%, O 7.93%
Literature References: Serotonin 5HT-receptor antagonist. Prepn: Bernardi et al., Gazz. Chim. Ital. 94, 936 (1964); Camerino et al., US 3238211 (1966 to Farmitalia). Pharmacology: C. Beretta et al., Nature 207, 421 (1965). Metabolic studies: Arcamone et al., Boll. Chim. Farm. 110, 704 (1971). Mode of action study: L. Krulich et al., Endocrinology 108, 1115 (1981). Clinical antiprolactin activity: F. Scapin et al., Eur. J. Clin. Pharmacol. 22, 181 (1982); A. Caballero et al., J. Reprod. Med. 32, 115 (1987).
Properties: Crystals from benzene + ether, mp 146-149°. [a]D28 -7 ±2°. uv max: 291 nm (E1%1cm 165). Very sol in pyridine; sol in alc, acetone, chloroform. Practically insol in benzene, ether, water. LD50 in mice (mg/kg): 85 i.p., 430 orally; in rats (mg/kg): >800 orally (Beretta).
Melting point: mp 146-149°
Optical Rotation: [a]D28 -7 ±2°
Absorption maximum: uv max: 291 nm (E1%1cm 165)
Toxicity data: LD50 in mice (mg/kg): 85 i.p., 430 orally; in rats (mg/kg): >800 orally (Beretta)
Therap-Cat: Prolactin inhibitor.
Therap-Cat-Vet: Prolactin inhibitor.
Keywords: Prolactin Inhibitor.