Home > Name List By 7 > 7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1, 2-dihydroquinazoline-6-sulfonamide

CAS No 17560-51-9 , 7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,
2-dihydroquinazoline-6-sulfonamide

  • Name: 7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,
    2-dihydroquinazoline-6-sulfonamide
  • Synonyms: 17560-51-9; Oldren; Mykrox;Zaroxolyn; Microx;7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,
    2-dihydroquinazoline-6-sulfonamide; Metenix; Metolazonum [INN-Latin]; Diulo; Metalozone;
  • CAS Registry Number:
  • Transport: 25kgs
  • Flash Point: 324.9 ºC
  • Boiling Point:
  • Density: 1.4 g/cm3
  • Refractive index: 1.624
  • Water Solubility: Soluble (Soluble in alcohol)
  • Safety Statements: Human systemic effects by ingestion: general anesthesia, convulsions, and muscle contractions. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits Cl−, SOx, and NOx.
  • Hazard Symbols: UN NO.
  • Flash Point: 324.9 ºC
  • EINECS: 241-539-3
  • Molecular Weight: 365.83454
  • InchiKey: AQCHWTWZEMGIFD-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,
    22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)
  • Molecular Formula: C16H16ClN3O3S
  • Molecular Structure:CAS No:17560-51-9 7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,<br />2-dihydroquinazoline-6-sulfonamide

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References of 7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,
2-dihydroquinazoline-6-sulfonamide
Title: Metolazone
CAS Registry Number: 17560-51-9
CAS Name: 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide
Synonyms: 7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide; 2-methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone
Manufacturers' Codes: SR-720-22
Trademarks: Metenix (Sanofi-Aventis); Mykrox (Celltech); Xuret (Galen); Zaroxolyn (Teofarma)
Molecular Formula: C16H16ClN3O3S
Molecular Weight: 365.83
Percent Composition: C 52.53%, H 4.41%, Cl 9.69%, N 11.49%, O 13.12%, S 8.77%
Literature References: Prepn: B. V. Shetty, US 3360518 (1967 to Wallace & Tiernan); B. V. Shetty et al., J. Med. Chem. 13, 886 (1970). Pharmacology: E. Belair et al., Arch. Int. Pharmacodyn. Ther. 177, 71 (1969); E. J. Belair, Res. Commun. Chem. Pathol. Pharmacol. 2, 98 (1971). HPLC determn in urine: D. Farthing et al., J. Chromatogr. 534, 228 (1990). Clinical evaluations as diuretic in chronic renal disease: R. Schoonees et al., N. Y. State J. Med. 71, 566 (1971); in hypertension: C. L. Curry et al., Clin. Ther. 9, 47 (1986); in congestive heart failure: A. Kiyingi et al., Lancet 335, 29 (1990).
Properties: Crystals from ethanol or butanol, mp 252-254°. LD50 in mice (mg/kg): >5000 orally; >1500 i.p. (Shetty, 1967).
Melting point: mp 252-254°
Toxicity data: LD50 in mice (mg/kg): >5000 orally; >1500 i.p. (Shetty, 1967)
Therap-Cat: Diuretic; antihypertensive.
Keywords: Antihypertensive; Thiazides and Analogs; Diuretic; Thiazides and Analogs.