References of Immunoglobulin G1,anti-(human CD20 (antigen)) (human-mouse monoclonal IDEC-C2B8 g1-chain), disulfide withhuman-mouse monoclonal IDEC-C2B8 k-chain, dimer
Title: Rituximab
CAS Registry Number: 174722-31-7
CAS Name: Anti-(human CD20 antigen) immunoglobulin G1 (human-mouse monoclonal IDEC-C2B8 g1-chain) disulfide with human-mouse monoclonal IDEC-C2B8 k-chain, dimer
Manufacturers' Codes: IDEC-C2B8
Trademarks: Mabthera (Roche); Rituxan (Genentech)
Literature References: Genetically engineered chimeric murine-human monoclonal antibody directed against the CD20 antigen found on normal and malignant B lymphocyte surfaces. Contains murine light and heavy-chain variable regions and g1 heavy-chain and k light chain human constant regions. Composed of 2 heavy chains of 451 amino acids and 2 light chains of 213 amino acids; approx mol wt 145 kD. Prepn: D. R. Anderson
et al., WO 9411026;
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et al., Haematologica 87, 189 (2002).
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Monoclonal Antibodies.
