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CAS No 17230-88-5 , Danazol

  • Name: Danazol
  • Synonyms: Danocrine; anatrol; Danazolum;Danazol; Winobanin; Danol; Danatrol; Chronogyn; Ladogal; Cyclomen;
  • CAS Registry Number:
  • Melting Point: 224.4-226.80C
  • Density: 1.21 g/cm3
  • Refractive index: 1.604
  • Safety Statements: R20/21/22;R63
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 241-270-1
  • Molecular Weight: 337.45528
  • InchiKey: POZRVZJJTULAOH-LHZXLZLDSA-N
  • InChI: InChI=1S/C22H27NO2/c1-4-22(24)10-8-18-16-6-5-15-11-19-14(13-23-25-19)12-
    20(15,2)17(16)7-9-21(18,22)3/h1,11,13,16-18,24H,5-10,12H2,2-3H3/t16-,
    17+,18+,20+,21+,22+/m1/s1
  • Risk Statements: S22;S36
  • Molecular Formula: C22H27NO2
  • Molecular Structure:CAS No:17230-88-5 Danazol

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17230-88-5 Danazol

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17230-88-5 (17a)-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol

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References of Danazol
Title: Danazol
CAS Registry Number: 17230-88-5
CAS Name: (17a)-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol
Synonyms: 1-ethynyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-10a,12a-dimethyl-1H-cyclopenta[7,8]phenanthro[3,2-d]isoxazol-1-ol; 17a-ethynyl-17b-hydroxy-4-androsteno[2,3-d]isoxazole
Manufacturers' Codes: Win-17757
Trademarks: Bonzol (Tokyo Tanabe); Cyclomen (Sanofi-Synthelabo); Danatrol (Sanofi-Synthelabo); Danocrine (Sanofi-Synthelabo); Danol (Sanofi-Synthelabo); Danoval (Krka); Ladogal (Sanofi-Synthelabo); Winobanin (Sanofi-Synthelabo)
Molecular Formula: C22H27NO2
Molecular Weight: 337.46
Percent Composition: C 78.30%, H 8.06%, N 4.15%, O 9.48%
Literature References: Anterior pituitary supressant. Anabolic steroid deriv of ethisterone, q.v., with mild androgenic side effects (an impeded androgen). Prepn: GB 905844 (1962 to Sterling Drug), C.A. 58, 6895c (1963); Manson et al., J. Med. Chem. 6, 1 (1963); Clinton, Manson, US 3135743 (1964 to Sterling Drug). Activity studies: Sherins et al., J. Clin. Endocrinol. Metab. 32, 522 (1971); Dmowski et al., Fertil. Steril. 22, 9 (1971). Clinical studies in endometriosis and other endocrine disorders: R. B. Greenblatt et al., ibid. 102. Series of articles on pharmacology, pharmacokinetics and clinical use: Drugs 19, 321-372 (1980). Use in idiopathic thrombocytopenic purpura: Y. S. Ahn et al., N. Engl. J. Med. 308, 1396 (1983); in hemophilia: H. R. Gralnick et al., ibid. 1393.
Properties: Crystals from acetone, mp 224.4-226.8°. [a]D25 +7.5° (ethanol); [a]D25 +21.9° (chloroform). uv max (ethanol): 286 nm (e 11300).
Melting point: mp 224.4-226.8°
Optical Rotation: [a]D25 +7.5° (ethanol); [a]D25 +21.9° (chloroform)
Absorption maximum: uv max (ethanol): 286 nm (e 11300)
Therap-Cat: Antigonadotropin.
Keywords: Antigonadotropin.