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CAS No 171335-80-1 , Exatecan

  • Name: Exatecan
  • Synonyms: 171335-80-1;Dx 8951;Exatecan;
  • CAS Registry Number:
  • Flash Point: 818.4 °C at 760 mmHg
  • Boiling Point: 818.4 °C at 760 mmHg
  • Density: 1.53 g/cm3
  • Refractive index: 1.734
  • Flash Point: 818.4 °C at 760 mmHg
  • Molecular Weight: 435.447583
  • InchiKey: ZVYVPGLRVWUPMP-FYSMJZIKSA-N
  • InChI: InChI=1S/C24H22FN3O4/c1-3-24(31)14-6-18-21-12(8-28(18)22(29)13(14)9-32-
    23(24)30)19-16(26)5-4-11-10(2)15(25)7-17(27-21)20(11)19/h6-7,16,31H,3-5,
    8-9,26H2,1-2H3/t16-,24-/m0/s1
  • Molecular Formula: C24H22FN3O4
  • Molecular Structure:CAS No:171335-80-1 Exatecan

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References of Exatecan
Title: Exatecan
CAS Registry Number: 171335-80-1
CAS Name: (1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo[de]pyrano[3￠,4￠:6,7]indolizino[1,2-b]quinoline-10,13-dione
Manufacturers' Codes: DX-8951
Molecular Formula: C24H22FN3O4
Molecular Weight: 435.45
Percent Composition: C 66.20%, H 5.09%, F 4.36%, N 9.65%, O 14.70%
Literature References: Topoisomerase I inhibitor; synthetic analogue of camptothecin, q.v. Prepn: H. Terasawa et al., EP 495432 (1992 to Daiichi); of mesylate: S. Kamihara et al., EP 737686; eidem, US 6552197 (1996, 2003 both to Daiichi). HPLC determn in mouse plasma: T. Oguma et al., Biol. Pharm. Bull. 24, 176 (2001). Clinical pharmacokinetics and evaluation in advanced leukemia: F. J. Giles et al., Clin. Cancer Res. 8, 2134 (2002); in advanced solid malignancies: M. A. Garrison et al., ibid. 9, 2527 (2003); in breast cancer: F. J. Esteva et al., Cancer 98, 900 (2003); in gastric cancer: J. A. Ajani et al., Invest. New Drugs 23, 479 (2005).
 
Derivative Type: Methanesulfonate dihydrate
CAS Registry Number: 197720-53-9; 169869-90-3 (anhydrous)
Synonyms: Exatecan mesylate
Manufacturers' Codes: DX-8951f
Molecular Formula: C24H22FN3O4.CH4O3S.2H2O
Molecular Weight: 567.58
Percent Composition: C 52.90%, H 5.33%, F 3.35%, N 7.40%, O 25.37%, S 5.65%
Properties: mp 245-255° (dec). Sol in water.
Melting point: mp 245-255° (dec)
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkaloids/Natural Products; Camptothecin Derivatives; Topoisomerase I Inhibitor.