Home > Name List By 5 > 5-[[(2R,3S)-2-[(1R)-1-[3, 5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl] methyl]-1,2-dihydro-1,2,4-tr...

CAS No 170729-80-3 , 5-[[(2R,3S)-2-[(1R)-1-[3,
5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]
methyl]-1,2-dihydro-1,2,4-triazol-3-one

  • Name: 5-[[(2R,3S)-2-[(1R)-1-[3,
    5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]
    methyl]-1,2-dihydro-1,2,4-triazol-3-one
  • Synonyms: L-754030; Emend (TN);5-[[(2R,3S)-2-[(1R)-1-[3,
    5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]
    methyl]-1,2-dihydro-1,2,4-triazol-3-one; CHEBI:499361; AC1OCFCG;170729-80-3; S1189_Selleck; Emend; MK-869; MK-0869;
  • CAS Registry Number:
  • Density: 1.51 g/cm3
  • Refractive index: 1.564
  • Molecular Weight: 534.426662
  • InchiKey: ATALOFNDEOCMKK-OITMNORJSA-N
  • InChI: InChI=1S/C23H21F7N4O3/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,
    29)30)37-20-19(13-2-4-17(24)5-3-13)34(6-7-36-20)11-18-31-21(35)33-32-18/
    h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-/m1/s1
  • Molecular Formula: C23H21F7N4O3
  • Molecular Structure:CAS No:170729-80-3 5-[[(2R,3S)-2-[(1R)-1-[3,<br />5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]<br />methyl]-1,2-dihydro-1,2,4-triazol-3-one
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170729-80-3 Aprepitant(MK-0869)

  • The substance P receptor antagonist MK-0869 shows antidepressant and anxiolytic activity in depressed outpatients which was comparable to a standard SSRI. More information please visit the website: http://www.creative-enzymes.com/product/Aprepitant-M...
  • Min. Order: 10
  • United States Creative Enzymes [Manufacturer]
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170729-80-3 Aprepitant

  • epitant, with CAS 170729-80-3, is an antiemetic chemical compound that belongs to a class of drugs called substance P antagonists (SPA). Aprepitant (CAS 170729-80-3) is effective in helping to prevent CINV because it antagonizes the NK1 receptor. Thi...
  • China Viwit [Manufacturer]
  • Tel: 86-21-37775618
  • Address: 507 Block B, Yingjia Plaza, 3008 Gudai Road Shanghai,ShanghaiChina
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170729-80-3 Aprepitant

  • Company has built a high standard R&D center which equipped first-class research instruments. The center includes synthesis laboratory, analytical laboratory, applied research laboratory. We also gathered a group of technical talents who were from ho...
  • China Novtect Limited Company [Manufacturer, Distributor/Wholesaler, Government ministry/Bureau/Commission]
  • Tel: 86-010-57297856
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  • Address: Building D-3, Zhongguancun Dongsheng Science Park, No. 66 Xixiaokou Road, Haidian District , Beijing,nullChina

170729-80-3 APREPITANT

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
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    Hong Kong null,nullHong kong
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170729-80-3 Aprepitant

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170729-80-3 Aprepitant

  • Product name: Aprepitant CAS No.: 170729-80-3 Molecular weight: 534.43 Molecular formula: C23H21F7N4O3 BONA BIO-CHEM TECHNOLOGY CO., LTD. —————————————————————— Aprepitant170729-80-3 Blonanserin 132810-10-7 Methotrexate 59-05-2 ...
  • Min. Order: 50000
  • FOB Price: USD999999 - 999999 /
  • China Bona Bio-chem Technology Co.,Ltd. [Manufacturer, Distributor/Wholesaler]
  • Tel: 86-527-86284366
  • Fax: --
  • Address: Shenzhen Road suqian,JiangsuChina

170729-80-3 Aprepitant

  • white or almost white powder Original: China Minimum Order: 1 kg or discussed Packing: Aluminium-plastic bag/drum
  • China Shanghai MABCT Medicine Technology Co., Ltd. [Manufacturer]
  • Tel: 86-21-58954816
  • Address: Room 613, No.780, CaiLun Road, Zhangjiang High-Tech Park Shanghai,nullChina
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170729-80-3 Aprepitant CAS NO.: 170729-80-3

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170729-80-3 Aprepitant

  • Aprepitant, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
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170729-80-3 Aprepitant

  • China Hangzhou Sage Chemical Co., Ltd. [Manufacturer]
  • Tel: +86-571-86818502
  • Fax: +86-571-86818503
  • Address: RM501 Tower A, New Youth Plaza, NO.8 Jia Shan Road, Hangzhou, Zhejiang 310014, null,ZhejiangChina
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References of 5-[[(2R,3S)-2-[(1R)-1-[3,
5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]
methyl]-1,2-dihydro-1,2,4-triazol-3-one
Title: Aprepitant
CAS Registry Number: 170729-80-3
CAS Name: 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one
Synonyms: (2R)-[(1R)-3,5-bis(trifluoromethyl)phenylethoxy]-(3S)-(4-fluoro)phenyl-4-(3-oxo-1,2,4-triazol-5-yl)methyl morpholine
Manufacturers' Codes: MK-0869
Trademarks: Emend (Merck & Co.)
Molecular Formula: C23H21F7N4O3
Molecular Weight: 534.43
Percent Composition: C 51.69%, H 3.96%, F 24.88%, N 10.48%, O 8.98%
Literature References: Selective neurokinin-1 (NK-1) receptor antagonist. Prepn: C. P. Dorn et al., WO 9516679; eidem, US 5719147 (1995, 1998 both to Merck & Co.); and pharmacology: J. J. Hale et al., J. Med. Chem. 41, 4607 (1998). Improved synthesis: K. M. J. Brands et al., J. Am. Chem. Soc. 125, 2129 (2003). LC/MS/MS determn in plasma: C. M. Chavez-Eng et al., J. Pharm. Biomed. Anal. 35, 1213 (2004). Clinical trial in prevention of cisplatin-induced emesis: S. Van Belle et al., Cancer 94, 3032 (2002); with granisetron and/or dexamethasone: D. Campos et al., J. Clin. Oncol. 19, 1759 (2001). Clinical pharmacokinetics: A. K. Majumdar et al., J. Clin. Pharmacol. 46, 291 (2006). Review of clinical experience in prevention of chemotherapy-induced nausea and vomiting (CINV): T. M. Dando, C. M. Perry, Drugs 64, 777-794 (2004); A. M. Massaro, K. L. Lenz, Ann. Pharmacother. 39, 77-85 (2005).
Properties: mp 255°. [a]D25 +69° (c = 1.00 in methanol). Sparingly sol in ethanol, isopropyl acetate; slightly sol in acetonitrile. Practically insol in water.
Melting point: mp 255°
Optical Rotation: [a]D25 +69° (c = 1.00 in methanol)
 
Derivative Type: Fosaprepitant dimeglumine
CAS Registry Number: 265121-04-8; 172673-20-0 (free acid)
CAS Name: 1-Deoxy-1-(methylamino)-D-glucitol [3-[[(2R,3S)-2-[(1R)-1-[bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate (2:1) (salt)
Manufacturers' Codes: MK-0517
Molecular Formula: C23H22F7N4O6P.2C7H17NO5
Molecular Weight: 1004.83
Percent Composition: C 44.23%, H 5.62%, F 13.23%, N 8.36%, O 25.48%, P 3.08%
Literature References: Water-soluble prodrug. Prepn: C. P. Dorn et al., WO 9523798; eidem, US 5691336 (1995, 1997 both to Merck & Co.); J. J. Hale et al., J. Med. Chem. 43, 1234 (2000).
 
Therap-Cat: Antiemetic.
Keywords: Antiemetic; Neurokinin Receptor Antagonist.