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CAS No 17035-90-4 , (2S)-2-amino-5-[(N'-methylcarbamimidoyl)amino]pentanoic acid

  • Name: (2S)-2-amino-5-[(N'-methylcarbamimidoyl)amino]pentanoic acid
  • Synonyms: N-Monomethyl-L-arginine;(2S)-2-amino-5-[(N'-methylcarbamimidoyl)amino]pentanoic acid;Targinine; tilargininum; targinina; targininum; CHEBI:28229; NG-monomethyl-L-argine; tilarginina; L-NMMA;
  • CAS Registry Number:
  • Flash Point: 191.3°C
  • Boiling Point: 392.7°Cat760mmHg
  • Density: 1.32g/cm3
  • Flash Point: 191.3°C
  • Molecular Weight: 188.22754
  • InchiKey: NTNWOCRCBQPEKQ-YFKPBYRVSA-N
  • InChI: InChI=1S/C7H16N4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13/h5H,2-4,8H2,1H3,(H,12,
    13)(H3,9,10,11)/t5-/m0/s1
  • Molecular Formula: C7H16N4O2
  • Molecular Structure:CAS No:17035-90-4 (2S)-2-amino-5-[(N'-methylcarbamimidoyl)amino]pentanoic acid

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17035-90-4 L-NMMA Acetate

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17035-90-4 L-NMMA ACETATE

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17035-90-4 L-NMMA ACETATE

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17035-90-4 TARGININE

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References of (2S)-2-amino-5-[(N'-methylcarbamimidoyl)amino]pentanoic acid
Title: NG-Methylarginine
CAS Registry Number: 17035-90-4
CAS Name: N5-[Imino(methylamino)methyl]-L-ornithine
Synonyms: tilarginine; targinine; NG-monomethyl-L-arginine; L-NMA
Molecular Formula: C7H16N4O2
Molecular Weight: 188.23
Percent Composition: C 44.67%, H 8.57%, N 29.77%, O 17.00%
Literature References: Nitric oxide synthase (NOS) inhibitor; naturally occurring analog of arginine. Isoln from bovine brain and prepn: T. Nakajima et al., Biochim. Biophys. Acta 230, 212 (1971). Improved prepn: J. L. Corbin, M. Reporter, Anal. Biochem. 57, 310 (1974); S. Pundak, M. Wilchek, J. Org. Chem. 46, 808 (1981); of acetate salt: W. Zhang et al., Synth. Commun. 24, 2789 (1994). Inhibition of NO release by endothelial cells: R. M. J. Palmer et al., Biochem. Biophys. Res. Commun. 153, 1251 (1988). Review of biological significance: J. Leiper, P. Vallance, Cardiovasc. Res. 43, 542-548 (1999). Clinical evaluation in cardiogenic shock: G. Cotter et al., Circulation 101, 1358 (2000).
Properties: Crystals from water-ethanol. [a]D25 +26° (c = 1 in 1N HCl).
Optical Rotation: [a]D25 +26° (c = 1 in 1N HCl)
 
Derivative Type: Acetate
CAS Registry Number: 53308-83-1
Molecular Formula: C7H16N4O2.C2H4O2
Molecular Weight: 248.28
Percent Composition: C 43.54%, H 8.12%, N 22.57%, O 25.78%
Properties: White granular solid. [a]D22 +9.5° (c = 0.10 in water). Sol in water.
Optical Rotation: [a]D22 +9.5° (c = 0.10 in water)
 
Use: Reagent to inhibit nitric oxide production in biological systems.
Therap-Cat: In treatment of cardiogenic shock.