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CAS No 16960-16-0 , a1-24-Corticotropin

  • Name: a1-24-Corticotropin
  • Synonyms: HumanACTH (1-24); Cortrosinta;a1-24-Corticotropin; 10: PN: WO03051390 PAGE: 52 claimed protein; Porcine ACTH (1-24); Synacthene-retard;(1-24)a-ACTH; Tetracosactrin; Synacthene; 1-24corticotropin (human); Ba 30920; Cortrophin S; b-Corticotrophin-(1-24)-tetracosapeptide; Tetracosapeptide; Tetracosactid; Cortrosyn;Nuvacthen Depot; b1-24-Tetracosactide;Synacthen; Cosyntropin;Corticotropin-(1-24); 8: PN: WO0069900 SEQID: 7 unclaimedsequence; PN: WO9952928 SEQID: 9 claimed protein; Synecthen; ACTHa1-24;Tetracosactide; L-Proline, L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-glutamyl-L-a-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-; 2136: PN: WO03060071 SEQID: 2198unclaimed; a1-24-Adrenocorticotropic hormone; a1-24-ACTH; 20: PN:WO2006052468 SEQID: 2 claimed sequence;b1-24-ACTH; 1-24 ACTH (human); 4: PN: WO2004045592 SEQID: 3 unclaimed sequence; Adrenocorticotropin(1-24); Actholain; b1-24-Corticotropin; ACTH1-24; 7: PN:US20090175821 SEQID: 7 claimed protein; Ba 36716;
  • CAS Registry Number:
  • Density: 1.476g/cm3
  • Refractive index: 1.681
  • EINECS: 241-031-1
  • Molecular Weight: 2933.437
  • InChI: InChI=1/C136H210N40O31S/c1-75(2)109(127(200)154-71-106(181)156-88(31-13-17-52-137)114(187)158-89(32-14-18-53-138)115(188)159-91(35-21-56-149-134(142)143)116(189)164-96(37-23-58-151-136(146)147)131(204)175-60-25-39-104(175)126(199)173-111(77(5)6)128(201)163-90(33-15-19-54-139)120(193)171-110(76(3)4)129(202)169-101(65-80-43-47-84(180)48-44-80)132(205)176-61-26-40-105(176)133(206)207)172-125(198)103-38-24-59-174(103)130(203)95(34-16-20-55-140)157-107(182)70-153-113(186)99(66-81-68-152-87-30-12-11-29-85(81)87)167-117(190)92(36-22-57-150-135(144)145)160-121(194)98(63-78-27-9-8-10-28-78)166-123(196)100(67-82-69-148-74-155-82)168-118(191)93(49-50-108(183)184)161-119(192)94(51-62-208-7)162-124(197)102(73-178)170-122(195)97(165-112(185)86(141)72-177)64-79-41-45-83(179)46-42-79/h8-12,27-30,41-48,68-69,74-77,86,88-105,109-111,152,177-180H,13-26,31-40,49-67,70-73,137-141H2,1-7H3,(H,148,155)(H,153,186)(H,154,200)(H,156,181)(H,157,182)(H,158,187)(H,159,188)(H,160,194)(H,161,192)(H,162,197)(H,163,201)(H,164,189)(H,165,185)(H,166,196)(H,167,190)(H,168,191)(H,169,202)(H,170,195)(H,171,193)(H,172,198)(H,173,199)(H,183,184)(H,206,207)(H4,142,143,149)(H4,144,145,150)(H4,146,147,151)/t86-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,109-,110-,111-/m0/s1
  • Molecular Formula: C136H210 N40 O31 S
  • Molecular Structure:CAS No:16960-16-0 a1-24-Corticotropin

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References of a1-24-Corticotropin
Title: Cosyntropin
CAS Registry Number: 16960-16-0
CAS Name: a1-24-Corticotropin
Synonyms: b1-24-corticotropin; tetracosactide
Trademarks: Cortrosyn (Amphastar)
Molecular Formula: C136H210N40O31S
Molecular Weight: 2933.44
Percent Composition: C 55.68%, H 7.22%, N 19.10%, O 16.91%, S 1.09%
Literature References: Synthetic polypeptide corresponding to the first 24 amino acids of ACTH, q.v. Identification of activity: R. G. Shepherd et al., J. Am. Chem. Soc. 78, 5067 (1956). Synthesis: H. Kappeler, R. Schwyzer, Helv. Chim. Acta 44, 1136 (1961); eidem, ibid. 46, 1550 (1963); solid-state synthesis: R. Matsueda et al., J. Am. Chem. Soc. 97, 2573 (1975). Assessment of hormone levels for adrenal function in cats: M. E. Peterson et al., Res. Vet. Sci. 37, 331 (1984); in dogs: L. A. Frank et al., Domest. Anim. Endocrinol. 24, 43 (2003). Review as diagnostic aid in assessment of secondary adrenal insufficiency: T. A. M. Abdu, R. N. Clayton, Curr. Opin. Endocrinol. Diabetes 7, 116-121 (2000); in primary or secondary adrenal insufficiency: R. I. Dorin et al., Ann. Intern. Med. 139, 194-204, E205-E206 (2003).
 
Derivative Type: Hexaacetate
CAS Registry Number: 22633-88-1
CAS Name: a1-24-Corticotropin hexaacetate (salt)
Trademarks: Synacthen (Novartis)
Properties: [a]D22 -88 ±2° (c = 0.511 in 1% acetic acid). uv max (0.1 N NaOH): 283, 289 nm (e 8550, 8810).
Optical Rotation: [a]D22 -88 ±2° (c = 0.511 in 1% acetic acid)
Absorption maximum: uv max (0.1 N NaOH): 283, 289 nm (e 8550, 8810)
 
Therap-Cat: Diagnostic aid (adrenal function).
Therap-Cat-Vet: Diagnostic aid (adrenal function).
Keywords: Diagnostic Aid.