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CAS No 167305-00-2 , (4S,7S,10aS)-5-oxo-4-[[(2S)-3-phenyl-2-sulfanylpropanoyl]amino]-2,3,4,7,
8,9,10,10a-octahydropyrido[2,1-b][1,3]thiazepine-7-carboxylic acid

  • Name: (4S,7S,10aS)-5-oxo-4-[[(2S)-3-phenyl-2-sulfanylpropanoyl]amino]-2,3,4,7,
    8,9,10,10a-octahydropyrido[2,1-b][1,3]thiazepine-7-carboxylic acid
  • Synonyms: Omapatrilat (JAN/USAN/INN); CHEBI:159756;BMS-186716; AC1LCVB7; D01970;(4S,7S,10aS)-5-oxo-4-[[(2S)-3-phenyl-2-sulfanylpropanoyl]amino]-2,3,4,7,
    8,9,10,10a-octahydropyrido[2,1-b][1,3]thiazepine-7-carboxylic acid; CHEMBL289556;
  • CAS Registry Number:
  • Flash Point: 391.8°C
  • Boiling Point: 724.2°Cat760mmHg
  • Density: 1.37g/cm3
  • Refractive index: 1.645
  • Flash Point: 391.8°C
  • Molecular Weight: 408.53486
  • InchiKey: LVRLSYPNFFBYCZ-VGWMRTNUSA-N
  • InChI: InChI=1S/C19H24N2O4S2/c22-17(15(26)11-12-5-2-1-3-6-12)20-13-9-10-27-16-
    8-4-7-14(19(24)25)21(16)18(13)23/h1-3,5-6,13-16,26H,4,7-11H2,(H,20,
    22)(H,24,25)/t13-,14-,15-,16-/m0/s1
  • Molecular Formula: C19H24N2O4S2
  • Molecular Structure:CAS No:167305-00-2 (4S,7S,10aS)-5-oxo-4-[[(2S)-3-phenyl-2-sulfanylpropanoyl]amino]-2,3,4,7,<br />8,9,10,10a-octahydropyrido[2,1-b][1,3]thiazepine-7-carboxylic acid

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167305-00-2 OMAPATRILAT/VANLEV

  • United States ChemPacific Corporation [Manufacturer]
  • Tel: 410-633-5771
  • Fax: 410-633-5808
  • Address: 6200 Freeport Center
    Baltimore, MD 21224, USA null,nullUnited States
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167305-00-2 826418 OMAPATRILAT/VANLEV

  • United States APAC Pharmaceutical, LLC [Manufacturer]
  • Tel: +1 (410) 469-0727
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References of (4S,7S,10aS)-5-oxo-4-[[(2S)-3-phenyl-2-sulfanylpropanoyl]amino]-2,3,4,7,
8,9,10,10a-octahydropyrido[2,1-b][1,3]thiazepine-7-carboxylic acid
Title: Omapatrilat
CAS Registry Number: 167305-00-2
CAS Name: (4S,7S,10aS)-Octahydro-4-[[(2S)-2-mercapto-1-oxo-3-phenylpropyl]amino]-5-oxo-7H-pyrido[2,1-b][1,3]thiazepine-7-carboxylic acid
Manufacturers' Codes: BMS-186716
Trademarks: Vanlev (BMS)
Molecular Formula: C19H24N2O4S2
Molecular Weight: 408.53
Percent Composition: C 55.86%, H 5.92%, N 6.86%, O 15.67%, S 15.70%
Literature References: Dual metalloprotease inhibitor of neutral endopeptidase (NEP) and angiotensin converting enzyme (ACE). Prepn: J. A. Robl et al., EP 629627; idem, US 5508272 (1994, 1996 both to Bristol-Myers Squibb); and pharmacological evaluation: idem et al., J. Med. Chem. 40, 1570 (1997). HPLC-MS determn in rat plasma: M. Jemal, D. J. Hawthorne, J. Chromatogr. B 698, 123 (1997). Antihypertensive activity in rats: N. C. Trippodo et al., Am. J. Hypertens. 11, 363 (1998). Clinical pharmacodynamics: C. Massien et al., Clin. Pharmacol. Ther. 65, 448 (1999). Review of pharmacology and clinical use: M. Weber, Am. J. Hypertens. 12, 139S-147S (1999). Clinical trial in heart failure: J. L. Rouleau et al., Lancet 356, 615 (2000).
Properties: Fine, white solid, mp 218-220°. [a]D -78.9° (c = 0.46 in DMF).
Melting point: mp 218-220°
Optical Rotation: [a]D -78.9° (c = 0.46 in DMF)
Therap-Cat: Antihypertensive.
Keywords: Vasopeptidase Inhibitor; Antihypertensive.