Home > Name List By 5 > 5-O-(butanoyloxymethyl) 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3, 5-dicarboxylate

CAS No 167221-71-8 , 5-O-(butanoyloxymethyl) 3-O-methyl
4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,
5-dicarboxylate

  • Name: 5-O-(butanoyloxymethyl) 3-O-methyl
    4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,
    5-dicarboxylate
  • Synonyms: Cleviprex; Cleviprex (TN); Clevidipine butyrate; H 324/38; rac-Clevidipine; 167221-71-8; Cleviprex; Clevidipine; Clevelox;5-O-(butanoyloxymethyl) 3-O-methyl
    4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,
    5-dicarboxylate;
  • CAS Registry Number:
  • Flash Point: 280.2°C
  • Boiling Point: 539.7°Cat760mmHg
  • Density: 1.289g/cm3
  • Flash Point: 280.2°C
  • Molecular Weight: 456.31642
  • InchiKey: KPBZROQVTHLCDU-UHFFFAOYSA-N
  • InChI: InChI=1S/C21H23Cl2NO6/c1-5-7-15(25)29-10-30-21(27)17-12(3)24-11(2)16(20
    (26)28-4)18(17)13-8-6-9-14(22)19(13)23/h6,8-9,18,24H,5,7,10H2,1-4H3
  • Molecular Formula: C21H23Cl2NO6
  • Molecular Structure:CAS No:167221-71-8 5-O-(butanoyloxymethyl) 3-O-methyl<br />4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,<br />5-dicarboxylate

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167221-71-8 Methyl (1-oxobutoxy)methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dime thyl-3,5-pyridinedicarboxylate; Clevidipine Butyrate; Cleviprex

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167221-71-8 High purity Clevidipine butyrate 167221-71-8

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References of 5-O-(butanoyloxymethyl) 3-O-methyl
4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,
5-dicarboxylate
Title: Clevidipine
CAS Registry Number: 167221-71-8
CAS Name: 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl (1-oxybutoxy)methyl ester
Synonyms: butyroxymethyl methyl 4-(2￠,3￠-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Trademarks: Clevelox (AstraZeneca)
Molecular Formula: C21H23Cl2NO6
Molecular Weight: 456.32
Percent Composition: C 55.27%, H 5.08%, Cl 15.54%, N 3.07%, O 21.04%
Literature References: Ultrashort-acting dihydropyridine calcium channel antagonist. Prepn: K. H. Andersson et al., WO 9512578; eidem, US 5856346 (1995, 1999 both to Astra). Improved prepn: A. Mattson et al., WO 0031035 (2000 to AstraZeneca). Capillary GC/MS determn in whole blood: C. Fakt, H. Stenhoff, J. Chromatogr. B 723, 211 (1999). Clinical pharmacokinetics: H. Ericsson et al., Br. J. Clin. Pharmacol. 47, 531 (1999); and pulmonary extraction during cardiopulmonary bypass: A. Vuylsteke et al., Br. J. Anaesth. 85, 683 (2000). Clinical evaluation in hypertension in postoperative cardiac surgical patients: N. Kieler-Jensen et al., Acta Anaesthesiol. Scand. 44, 186 (2000); J. M. Bailey et al., Anesthesiology 96, 1086 (2002). Review of pharmacology and clinical development: M. Nordlander et al., Cardiovasc. Drug Rev. 22, 227-250 (2004).
Properties: Crystals from diisopropylether, mp 136.2-138.5°. Soly in water: 0.1 mg/ml.
Melting point: mp 136.2-138.5°
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Dihydropyridine Derivatives; Calcium Channel Blocker; Dihydropyridine Derivatives.