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CAS No 162652-95-1 , Vinflunine

  • Name: Vinflunine
  • Synonyms: 4'-deoxy-20',20'-difluoro-; SureCN1652401; AC1L4IHN;162652-95-1; C45H54F2N4O8; Vinflunine [INN};Vinflunine; C'-Norvincaleukoblastine; UNII-5BF646324K;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.39 g/cm3
  • Refractive index: 1.652
  • Flash Point: °C
  • Molecular Weight: 816.929066
  • InchiKey: NMDYYWFGPIMTKO-ZSRSGXGDSA-N
  • InChI: InChI=1S/C45H54F2N4O8/c1-8-42-14-11-16-51-17-15-43(36(42)51)30-19-31(34
    (56-5)20-33(30)49(4)37(43)45(55,
    40(54)58-7)38(42)59-25(2)52)44(39(53)57-6)21-26-18-27(41(3,
    46)47)23-50(22-26)24-29-28-12-9-10-13-32(28)48-35(29)44/h9-14,19-20,
    26-27,36-38,48,55H,8,15-18,21-24H2,1-7H3/t26-,27-,36-,37+,38+,42+,43+,
    44-,45-/m0/s1
  • Molecular Formula: C45H54F2N4O8
  • Molecular Structure:CAS No:162652-95-1 Vinflunine

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References of Vinflunine
Title: Vinflunine
CAS Registry Number: 162652-95-1
CAS Name: (2b,3b,4b,5a,12R,19a)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylic acid methyl ester
Synonyms: 4￠-deoxy-20￠,20￠-difluoro-8￠-norvincaleukoblastine; 20￠,20￠-difluoro-3￠,4￠-dihydrovinorelbine
Molecular Formula: C45H54F2N4O8
Molecular Weight: 816.93
Percent Composition: C 66.16%, H 6.66%, F 4.65%, N 6.86%, O 15.67%
Literature References: Semisynthetic Vinca alkaloid with microtubule destabilizing and antiangiogenic activity; derivative of vinorelbine, q.v. Prepn: J.-C. Jacquesy et al., FR 2707988; eidem, US 5620985 (1995, 1997 both to Pierre Fabre); J. Fahy et al., J. Am. Chem. Soc. 119, 8576 (1997). NMR study of tubulin binding: C. Fabre et al., Biochem. Pharmacol. 64, 733 (2002). Clinical pharmacokinetics and evaluation in solid tumors: J. Bennouna et al., Ann. Oncol. 14, 630 (2003). Clinical evaluation in bladder cancer: S. Culine et al., Br. J. Cancer 2006, 1. Review of clinical development and mechanism of action: A. Kruczynski, B. T. Hill, Crit. Rev. Oncol. Hematol. 40, 159-173 (2001); J. Bennouna et al. Expert Opin. Invest. Drugs 14, 1259-1267 (2005).
 
Derivative Type: Ditartrate
CAS Registry Number: 194468-36-5
Trademarks: Javlor (Fabre)
Molecular Formula: C45H54F2N4O8.2C4H6O6
Molecular Weight: 1117.10
Percent Composition: C 56.98%, H 5.96%, F 3.40%, N 5.02%, O 28.64%
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkaloids/Natural Products; Vinca Alkaloids.