Home > Name List By other > [(3S)-oxolan-3-yl] N-[(2S, 3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1- phenylbutan-2-yl]carbamate

CAS No 161814-49-9 , [(3S)-oxolan-3-yl]
N-[(2S,
3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-
phenylbutan-2-yl]carbamate

  • Name: [(3S)-oxolan-3-yl]
    N-[(2S,
    3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-
    phenylbutan-2-yl]carbamate
  • Synonyms: 161814-49-9; Vertex; amprenavir[usan];Agenerase; 141W94; VX-478; Prozei; VX 478; Vertex VX478;[(3S)-oxolan-3-yl]
    N-[(2S,
    3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-
    phenylbutan-2-yl]carbamate;
  • CAS Registry Number:
  • Density: 1.3 g/cm3
  • Refractive index: 1.61
  • Molecular Weight: 505.6269
  • InchiKey: YMARZQAQMVYCKC-OEMFJLHTSA-N
  • InChI: InChI=1S/C25H35N3O6S/c1-18(2)15-28(35(31,
    32)22-10-8-20(26)9-11-22)16-24(29)23(14-19-6-4-3-5-7-19)27-25(30)34-21-
    12-13-33-17-21/h3-11,18,21,23-24,29H,12-17,26H2,1-2H3,(H,27,30)/t21-,
    23-,24+/m0/s1
  • Molecular Formula: C25H35N3O6S
  • Molecular Structure:CAS No:161814-49-9 [(3S)-oxolan-3-yl]<br />N-[(2S,<br />3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-<br />phenylbutan-2-yl]carbamate

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References of [(3S)-oxolan-3-yl]
N-[(2S,
3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-
phenylbutan-2-yl]carbamate
Title: Amprenavir
CAS Registry Number: 161814-49-9
CAS Name: [(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3S)-tetrahydro-3-furanyl ester
Synonyms: 4-amino-N-((2syn,3S)-2-hydroxy-4-phenyl-3-((S)-tetrahydrofuran-3-yloxycarbonylamino)-butyl)-N-isobutylbenzene sulfonamide
Manufacturers' Codes: 141W94; KVX-478; VX-478
Trademarks: Agenerase (GSK); Prozei (Kissei)
Molecular Formula: C25H35N3O6S
Molecular Weight: 505.63
Percent Composition: C 59.38%, H 6.98%, N 8.31%, O 18.99%, S 6.34%
Literature References: Second generation HIV protease inhibitor. Prepn: R. D. Tung et al., WO 9405639; eidem, US 5585397 (1994, 1996 both to Vertex). Crystal structure of complex with HIV protease: E. E. Kim et al., J. Am. Chem. Soc. 117, 1181 (1995). Review of design strategy: M. A. Navia et al., Int. Antiviral News 3, 143-145 (1995); of pharmacology and clinical evaluation: J. C. Adkins, D. Faulds, Drugs 55, 837-842 (1998).
Properties: White to cream-colored solid. Soly in water (25°): 0.04 mg/ml.
Therap-Cat: Antiviral.
Keywords: HIV Protease Inhibitor; Antiviral; Peptidomimetics.