Home > Name List By 1 > 1H-Carbazole-6-carboxamide,2,3,4,9-tetrahydro-3-(methylamino)-, (3R)-

CAS No 158747-02-5 , 1H-Carbazole-6-carboxamide,2,3,4,9-tetrahydro-3-(methylamino)-, (3R)-

  • Name: 1H-Carbazole-6-carboxamide,2,3,4,9-tetrahydro-3-(methylamino)-, (3R)-
  • Synonyms: 1H-Carbazole-6-carboxamide,2,3,4,9-tetrahydro-3-(methylamino)-, (R)-;1H-Carbazole-6-carboxamide,2,3,4,9-tetrahydro-3-(methylamino)-, (3R)-;Frovatriptan; SB 209509; Migard; Miguard; (R)-Frovatriptan; Frova;
  • CAS Registry Number:
  • Flash Point: 265.4°C
  • Boiling Point: 515.2°Cat760mmHg
  • Density: 1.27g/cm3
  • Refractive index: 1.667
  • Flash Point: 265.4°C
  • Molecular Weight: 0
  • InChI: InChI=1/C14H17N3O/c1-16-9-3-5-13-11(7-9)10-6-8(14(15)18)2-4-12(10)17-13/h2,4,6,9,16-17H,3,5,7H2,1H3,(H2,15,18)
  • Molecular Formula: C14H17 N3 O
  • Molecular Structure:CAS No:158747-02-5 1H-Carbazole-6-carboxamide,2,3,4,9-tetrahydro-3-(methylamino)-, (3R)-

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References of 1H-Carbazole-6-carboxamide,2,3,4,9-tetrahydro-3-(methylamino)-, (3R)-
Title: Frovatriptan
CAS Registry Number: 158747-02-5
CAS Name: (3R)-2,3,4,9-Tetrahydro-3-(methylamino)-1H-carbazole-6-carboxamide
Synonyms: 3-methylamino-6-carboxamido-1,2,3,4-tetrahydrocarbazole
Manufacturers' Codes: SB-209509
Molecular Formula: C14H17N3O
Molecular Weight: 243.30
Percent Composition: C 69.11%, H 7.04%, N 17.27%, O 6.58%
Literature References: Serotonin 5-HT1B/1D receptor agonist. Prepn: F. D. King et al., WO 9300086; eidem, US 5464864 (1993, 1995 both to SmithKline Beecham). Pharmacology: A. A. Parsons et al., J. Cardiovasc. Pharmacol. 30, 136 (1997). Series of articles on pharmacology, safety and clinical studies: Headache 42, Suppl. 2, S45-S99 (2002). Review of clinical experience in cluster headaches: H. C. Siow et al., Cephalalgia 24, 1045-1048 (2004); in acute migraine: N. Poolsup et al., J. Clin. Pharm. Ther. 30, 521-532 (2005).
 
Derivative Type: Succinate monohydrate
CAS Registry Number: 158930-17-7; 158930-09-7 (anhydrous)
Manufacturers' Codes: SB-209509AX; VML-251
Trademarks: Frova (Vernalis); Frovelan (Elan); Migard (Vernalis); Miguard (Vernalis)
Molecular Formula: C14H17N3O.C4H6O4.H2O
Molecular Weight: 379.41
Percent Composition: C 56.98%, H 6.64%, N 11.08%, O 25.30%
Properties: White to off-white powder. Sol in water.
 
Therap-Cat: Antimigraine.
Keywords: Antimigraine; Serotonin Receptor Agonist.