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CAS No 158382-37-7 , (2S)-2-amino-5-[[(2R)-2-amino-3-[2-[bis[bis(2-chloroethyl)amino]
phosphoryloxy]ethylsulfonyl]propanoyl]-[(R)-carboxy(phenyl)methyl]amino]
-5-oxopentanoic acid

  • Name: (2S)-2-amino-5-[[(2R)-2-amino-3-[2-[bis[bis(2-chloroethyl)amino]
    phosphoryloxy]ethylsulfonyl]propanoyl]-[(R)-carboxy(phenyl)methyl]amino]
    -5-oxopentanoic acid
  • Synonyms: SureCN1651418; AC1L322U; UNII-1RS284BFUI;Canfosfamide [INN];(2S)-2-amino-5-[[(2R)-2-amino-3-[2-[bis[bis(2-chloroethyl)amino]
    phosphoryloxy]ethylsulfonyl]propanoyl]-[(R)-carboxy(phenyl)methyl]amino]
    -5-oxopentanoic acid;
  • CAS Registry Number:
  • Flash Point: 522.2°C
  • Boiling Point: 939.8°Cat760mmHg
  • Density: 1.484g/cm3
  • Refractive index: 1.587
  • Flash Point: 522.2°C
  • Molecular Weight: 787.474062
  • InchiKey: VESKBLGTHHPZJF-QNWVGRARSA-N
  • InChI: InChI=1S/C26H40Cl4N5O10PS/c27-8-12-33(13-9-28)46(42,
    34(14-10-29)15-11-30)45-16-17-47(43,
    44)18-21(32)24(37)35(22(36)7-6-20(31)25(38)39)23(26(40)41)19-4-2-1-3-5-
    19/h1-5,20-21,23H,6-18,31-32H2,(H,38,39)(H,40,41)/t20-,21-,23+/m0/s1
  • Molecular Formula: C26H40Cl4N5O10PS
  • Molecular Structure:CAS No:158382-37-7 (2S)-2-amino-5-[[(2R)-2-amino-3-[2-[bis[bis(2-chloroethyl)amino]<br />phosphoryloxy]ethylsulfonyl]propanoyl]-[(R)-carboxy(phenyl)methyl]amino]<br />-5-oxopentanoic acid

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References of (2S)-2-amino-5-[[(2R)-2-amino-3-[2-[bis[bis(2-chloroethyl)amino]
phosphoryloxy]ethylsulfonyl]propanoyl]-[(R)-carboxy(phenyl)methyl]amino]
-5-oxopentanoic acid
Title: Canfosfamide
CAS Registry Number: 158382-37-7
CAS Name: (2R)-L-g-Glutamyl-3-[[2-[[bis[bis(2-chloroethyl)amino]phosphinyl]oxy]ethyl]sulfonyl]-L-alanyl-2-phenylglycine
Synonyms: g-glutamyl-a-amino-b-((2-ethyl-N,N,N￠,N￠-tetrakis(2-chloro)ethylphosphoramidate)sulfonyl)propionyl-(R)-(-)phenylglycine
Manufacturers' Codes: TER-286
Molecular Formula: C26H40Cl4N5O10PS
Molecular Weight: 787.47
Percent Composition: C 39.66%, H 5.12%, Cl 18.01%, N 8.89%, O 20.32%, P 3.93%, S 4.07%
Literature References: Nitrogen mustard prodrug preferentially activated by glutathione S-transferase P1-1. Prepn: M. H. Lyttle et al., J. Med. Chem. 37, 1501 (1994); L. M. Kauvar et al., WO 9509866; eidem, US 5556942 (1995, 1996 both to Terrapin). Mechanism of activation: A. Satyam et al., J. Med. Chem. 39, 1736 (1996). In vitro and in vivo antitumor and myelosuppressive effects: A. S. Morgan et al., Cancer Res. 58, 2568 (1998). Clinical pharmacokinetics and toxicology in advanced solid malignancies: L. S. Rosen et al., Clin. Cancer Res. 9, 1628 (2003); idem et al., ibid. 10, 3689 (2004).
Properties: White solid, mp 82-90°.
Melting point: mp 82-90°
 
Derivative Type: Hydrochloride
CAS Registry Number: 439943-59-6
Manufacturers' Codes: TLK-286
Trademarks: Telcyta (Telik)
Molecular Formula: C26H40Cl4N5O10PS.HCl
Molecular Weight: 823.94
Percent Composition: C 37.90%, H 5.02%, Cl 21.51%, N 8.50%, O 19.42%, P 3.76%, S 3.89%
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkylating Agents; Nitrogen Mustards.