Home > Name List By 3 > 3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3, 5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2, 5-dihydro-1H-3-benz...

CAS No 155974-00-8 , 3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,
5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,
5-dihydro-1H-3-benzazepin-4-one

  • Name: 3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,
    5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,
    5-dihydro-1H-3-benzazepin-4-one
  • Synonyms: S-16257;Procoralan; S-16257-2; S 16257; 155974-00-8; Ivabradine (INN);3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,
    5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,
    5-dihydro-1H-3-benzazepin-4-one; S 16257-2; Ivabradine [INN];
  • CAS Registry Number:
  • Flash Point: 332.9ºC
  • Boiling Point: 626.9 ºCat 760 mmHg
  • Density: 1.146 g/cm3
  • Refractive index: 1.56
  • Flash Point: 332.9ºC
  • Molecular Weight: 468.58514
  • InchiKey: ACRHBAYQBXXRTO-OAQYLSRUSA-N
  • InChI: InChI=1S/C27H36N2O5/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-
    6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30/h12-14,16,21H,
    6-11,15,17H2,1-5H3/t21-/m1/s1
  • Molecular Formula: C27H36N2O5
  • Molecular Structure:CAS No:155974-00-8 3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,<br />5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,<br />5-dihydro-1H-3-benzazepin-4-one

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References of 3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,
5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,
5-dihydro-1H-3-benzazepin-4-one
Title: Ivabradine
CAS Registry Number: 155974-00-8
CAS Name: 3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one
Synonyms: 7,8-dimethoxy-3-[3-[[(1S)-(4,5-dimethoxybenzocyclobutan-1-yl)methyl]methylamino]propyl]-1,3,4,5-tetrahydro-2H-benzazepin-2-one
Manufacturers' Codes: S-16257
Molecular Formula: C27H36N2O5
Molecular Weight: 468.59
Percent Composition: C 69.21%, H 7.74%, N 5.98%, O 17.07%
Literature References: Selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Prepn: J.-L. Peglion et al., EP 534859; eidem, US 5296482 (1993, 1994 both to ADIR). In vitro electrophysiological effects: C. Thollon et al,. Br. J. Pharmacol. 112, 37 (1994). LC-MS determn in plasma: M. Fran?ois-Bouchard et al., J. Chromatogr. B 745, 261 (2000). Clinical pharmacokinetics: I. Ragueneau et al., Clin. Pharmacol. Ther. 64, 192 (1998). Clinical trial in stable angina: J. S. Borer et al., Circulation 107, 817 (2003). Series of articles on pharmacology and clinical experience: Eur. Heart J. Suppl. 5, Suppl. G, G26-G56 (2003). Review of mechanism of action: D. DiFrancesco, J. A. Camm, Drugs 64, 1757-1765 (2004).
 
Derivative Type: Hydrochloride
CAS Registry Number: 148849-67-6
Manufacturers' Codes: S-16257-2
Trademarks: Procoralan (Servier); Corlentor (Servier)
Molecular Formula: C27H36N2O5.HCl
Molecular Weight: 505.05
Percent Composition: C 64.21%, H 7.38%, N 5.55%, O 15.84%, Cl 7.02%
Properties: Crystals from acetonitrile, mp 135-140°. [a]58921 +7.8°; [a]36521 +27.8° (c = 1% in DMSO).
Melting point: mp 135-140°
Optical Rotation: [a]58921 +7.8°; [a]36521 +27.8° (c = 1% in DMSO)
 
Derivative Type: (±)-Form
CAS Registry Number: 149470-60-0
Molecular Formula: C27H36N2O5
Molecular Weight: 468.59
Percent Composition: C 69.21%, H 7.74%, N 5.98%, O 17.07%
Properties: Crystals from ethyl acetate, mp 101-103°.
Melting point: mp 101-103°
 
Therap-Cat: Antianginal.
Keywords: Antianginal.