Home > Name List By 4 > 4-(4,5-dihydrobenzo[1,2]cyclohepta[3, 4-b]thiophen-10-ylidene)-1-methylpiperidine

CAS No 15574-96-6 , 4-(4,5-dihydrobenzo[1,2]cyclohepta[3,
4-b]thiophen-10-ylidene)-1-methylpiperidine

  • Name: 4-(4,5-dihydrobenzo[1,2]cyclohepta[3,
    4-b]thiophen-10-ylidene)-1-methylpiperidine
  • Synonyms: 15574-96-6; PIZOTYLINE;Pizotifen; Pizotifene; Sandomygran;4-(4,5-dihydrobenzo[1,2]cyclohepta[3,
    4-b]thiophen-10-ylidene)-1-methylpiperidine; Sandomigran; Pizotifenum; Litec; Polomigran; Pizotifeno;
  • CAS Registry Number:
  • Flash Point: 217.9°C
  • Boiling Point: 436.7°Cat760mmHg
  • Density: 1.164g/cm3
  • Refractive index: 1.63
  • Safety Statements: 26-37/39
  • Hazard Symbols: Xi
  • Flash Point: 217.9°C
  • EINECS: 239-632-9
  • Molecular Weight: 295.44174
  • InchiKey: FIADGNVRKBPQEU-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H21NS/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17
    (19)10-13-21-18/h2-5,10,13H,6-9,11-12H2,1H3
  • Risk Statements: 36/37/38
  • Molecular Formula: C19H21NS
  • Molecular Structure:CAS No:15574-96-6 4-(4,5-dihydrobenzo[1,2]cyclohepta[3,<br />4-b]thiophen-10-ylidene)-1-methylpiperidine

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References of 4-(4,5-dihydrobenzo[1,2]cyclohepta[3,
4-b]thiophen-10-ylidene)-1-methylpiperidine
Title: Pizotyline
CAS Registry Number: 15574-96-6
CAS Name: 4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine
Synonyms: 4-(1-methyl-4-piperidylidene)-9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophene; pizotifen; pizotifan
Manufacturers' Codes: BC-105
Molecular Formula: C19H21NS
Molecular Weight: 295.44
Percent Composition: C 77.24%, H 7.16%, N 4.74%, S 10.85%
Literature References: Serotonin antagonist structurally related to cyproheptadine, q.v. Prepn: Jucker et al., BE 636717 and US 3272826 (1964, 1966 to Sandoz); Bastian et al., Helv. Chim. Acta 49, 214 (1966). Toxicity data: Bagdon, Dorado, Pharmacologist 12, No. 2, 297 (1970). Mechanism of action study: E. Müller-Schweinitzer, J. Cardiovasc. Pharmacol. 8, 805 (1986). Clinical trial in migraine: D. Crowder, W. P. Maclay, Curr. Med. Res. Opin. 9, 280 (1984). Review of pharmacology and therapeutic efficacy: Speight, Avery, Drugs 3, 159-203 (1972).
 
Derivative Type: Hydrochloride
CAS Registry Number: 73391-87-4
Properties: Crystals from isopropanol-ether, mp 261-263° (dec).
Melting point: mp 261-263° (dec)
 
Derivative Type: Malate
CAS Registry Number: 5189-11-7
Trademarks: Litec (Novartis); Sandomigran (Novartis); Sanmigran (Novartis); Sanomigran (Novartis); Mosegor (Novartis)
Molecular Formula: C19H21NS.C4H6O5
Molecular Weight: 429.53
Percent Composition: C 64.31%, H 6.34%, N 3.26%, S 7.47%, O 18.62%
Properties: Crystals from methanol, mp 185-186° (dec).
Melting point: mp 185-186° (dec)
 
Therap-Cat: Antimigraine; appetite stimulant.
Keywords: Anabolic; Antidepressant; Tricyclics; Antimigraine.