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CAS No 15489-16-4 , Antimonate(5-),bis[4,5-di(hydroxy-kO)-1,3-benzenedisulfonato(4-)]-, sodium, hydrate (1:5:7), (T-4)-

  • Name: Antimonate(5-),bis[4,5-di(hydroxy-kO)-1,3-benzenedisulfonato(4-)]-, sodium, hydrate (1:5:7), (T-4)-
  • Synonyms: 1,3-Benzenedisulfonic acid, 4,5-dihydroxy-, antimony complex;Antimonate(5-),bis[4,5-di(hydroxy-kO)-1,3-benzenedisulfonato(4-)]-, sodium, hydrate (1:5:7), (T-4)-; Sodium antimony(III)bis(pyrocatechol-3,5-disulfonate) heptahydrate; Antimonate(5-),bis[4,5-dihydroxy-m-benzenedisulfonato(4-)]-, pentasodium, heptahydrate (8CI);Stibophen (7CI);Fouadin; Fuadine;Antimonate(5-),bis[4,5-di(hydroxy-kO)-1,3-benzenedisulfonato(4-)]-, pentasodium, heptahydrate, (T-4)- (9CI); Stibofen;Antimonate(5-), bis[4,5-dihydroxy-1,3-benzenedisulfonato(4-)-O4,O5]-,pentasodium, heptahydrate, (T-4)-; Pyrostib;
  • CAS Registry Number:
  • Safety Statements: Poison by intraperitoneal, intramuscular, and intravenous routes. Moderately toxic by intraperitoneal route. See also O.
  • Molecular Weight: 799.24
  • InChI: InChI=1/2C6H6O8S2.5Na.7H2O.Sb/c2*7-4-1-3(15(9,10)11)2-5(6(4)8)16(12,13)14;;;;;;;;;;;;;/h2*1-2,7-8H,(H,9,10,11)(H,12,13,14);;;;;;7*1H2;/q;;5*+1;;;;;;;;+3/p-8
  • Molecular Formula: C12H4 O16 S4 Sb . 7 H2 O . 5 Na
  • Molecular Structure:CAS No:15489-16-4 Antimonate(5-),bis[4,5-di(hydroxy-kO)-1,3-benzenedisulfonato(4-)]-, sodium, hydrate (1:5:7), (T-4)-

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15489-16-4 STIBOPHEN

  • United States 2A PharmaChem USA [Manufacturer]
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15489-16-4 STIBOPHEN

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References of Antimonate(5-),bis[4,5-di(hydroxy-kO)-1,3-benzenedisulfonato(4-)]-, sodium, hydrate (1:5:7), (T-4)-
Title: Stibophen
CAS Registry Number: 15489-16-4
CAS Name: (T-4)-Bis[4,5-dihydroxy-1,3-benzenedisulfonato(4-)-O4,O5]-antimonate(5-) pentasodium heptahydrate
Synonyms: sodium antimony bis(pyrocatechol-2,4-disulfonate) heptahydrate; antimony pyrocatechol sodium disulfonate heptahydrate
Manufacturers' Codes: Sdt-91
Trademarks: Fuadin (Winthrop); Fouadin; Fantorin (Glaxo); Neoantimosan; Repodral (Winthrop)
Molecular Formula: C12H4Na5O16S4Sb.7H2O
Molecular Weight: 895.23
Percent Composition: C 16.10%, H 2.03%, Na 12.84%, O 41.11%, S 14.33%, Sb 13.60%
Literature References: Prepn of potassium salt: GB 213285 (1923 to Heyden). Prepn from sodium pyrocatechol-3,5-disulfonate and antimony trioxide in alkaline soln: H. Schmidt, DE 448800 (1924 to I. G. Farbenind.), Frdl. 16, 2546 (1931); idem, US 1549154 (1925); idem, Z. Angew. Chem. 43, 963 (1930); idem, US 1873668 (1932 to Winthrop). Toxicity: H. Eagle et al., J. Pharmacol. Exp. Ther. 89, 196 (1947). Clinical trial in schistosomiasis: J. Azar et al., Am. J. Trop. Med. 29, 595 (1949); in leishmaniasis: H. S. Girgla et al., Br. J. Dermatol. 97, 307 (1977). UV spectrophotometric analysis: A. Besada et al., Anal. Lett. 21, 447 (1988).
Properties: Fine crystals. Almost insol in abs alcohol, ether, chloroform, acetone, petr ether. Readily sol in cold water. Unless the colorless neutral water soln is acidified it acquires a yellowish tint and finally reaches lemon-yellow color. LD50 i.v. in rabbits: ~90 mg/kg (Eagle).
Toxicity data: LD50 i.v. in rabbits: ~90 mg/kg (Eagle)
 
Derivative Type: Potassium salt
Synonyms: Antimosan; Heyden 611
 
Therap-Cat: Anthelmintic (Schistosoma).
Therap-Cat-Vet: Has been used in schistosomiasis.
Keywords: Anthelmintic (Schistosoma).