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CAS No 12550-17-3 , Antimonate(1-),[D-gluconato(4-)]-, sodium

  • Name: Antimonate(1-),[D-gluconato(4-)]-, sodium
  • Synonyms: Gluconicacid, antimony sodium deriv. (6CI); Triostam; D-Gluconic acid, antimony complex; Sodiumantimony gluconate; Triostib; Sodium antimonylgluconate;Antimonate(1-),[D-gluconato(4-)]-, sodium;
  • CAS Registry Number:
  • Safety Statements: Poison by intraperitoneal route. See also O.
  • EINECS: 235-699-3
  • Molecular Weight: 336.88
  • InChI: InChI=1/C6H9O7.Na.Sb/c7-1-2(8)3(9)4(10)5(11)6(12)13;;/h2-5,10-11H,1H2,(H,12,13);;/q-3;+1;+3/p-1/rC6H9O7Sb.Na/c7-3(4(8)6(9)10)5-2-1-11-14(12-2)13-5;/h2-5,7-8H,1H2,(H,9,10);/q;+1/p-1
  • Molecular Formula: C6H8 O7 Sb . Na

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12550-17-3 SODIUM ANTIMONY GLUCONATE

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12550-17-3 Sodium Antimony Gluconate

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References of Antimonate(1-),[D-gluconato(4-)]-, sodium
Title: Antimony Sodium Gluconate
Literature References: General term referring to either a trivalent or pentavalent antimony complex with sodium gluconate. Pentavalent compound may require reduction in vivo to the trivalent form to be bioactive. Determn in biological materials and pharmacodynamics: R. J. Ward et al., Clin. Chim. Acta 99, 143 (1979). Mechanism of action study: J. C. Mottram, G. H. Coombs, Exp. Parasitol. 59, 151 (1985).
 
Derivative Type: Sodium antimonylgluconate
CAS Registry Number: 12550-17-3
Molecular Formula: C6H8NaO7Sb
Molecular Weight: 336.87
Percent Composition: C 21.39%, H 2.39%, Na 6.82%, O 33.25%, Sb 36.14%
Literature References: Trivalent antimony compound. Prepn: Das Gupta, Indian J. Pharm. 15, 84 (1953); A. Axon et al., US 3306921 (1967 to Burroughs Wellcome). Antiparasitic activity: N. Ercoli et al., Chemotherapy 26, 254 (1980).
Properties: White, amorphous powder. Sol in water. Insol in organic solvents. pH of 2% aq soln 9-10; the soln at this pH is unstable.
 
Derivative Type: Sodium stibogluconate
CAS Registry Number: 16037-91-5
CAS Name: 2,4:2￠,4￠-O-(Oxydistibylidyne)bis[D-gluconic acid] Sb,Sb￠-dioxide trisodium salt nonahydrate
Trademarks: Pentostam (GSK); Solustibosan (Bayer)
Molecular Formula: C12H17Na3O17Sb2.9H2O
Molecular Weight: 907.88
Percent Composition: C 15.88%, H 3.89%, Na 7.60%, O 45.82%, Sb 26.82%
Literature References: Pentavalent antimony compound. Prepn: Datta, Ghosh, Sci. Cult. 11, 699 (1945-6); Bose, Ghosh, Indian J. Pharm. 11, 155 (1949). Pharmacokinetics: J. D. Chulay et al., Trans. R. Soc. Trop. Med. Hyg. 82, 69 (1988). Review of clinical safety and efficacy in leishmaniasis: B. L. Herwaldt, J. D. Berman, Am. J. Trop. Med. Hyg. 46, 296 (1992).
Properties: Crystals. Freely sol in water. pH of 10% aq soln 5.4-5.6.
 
Therap-Cat: Trivalent compd as an anthelmintic (Schistosoma); pentavalent compd as an antiprotozoal (Leishmania).