Home > Name List By other > (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3, 1-benzoxazin-2-one

CAS No 154598-52-4 , (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,
1-benzoxazin-2-one

  • Name: (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,
    1-benzoxazin-2-one
  • Synonyms: DMP-266; DMP 266;Sustiva; (S)-isomer; efavirenz; 1ikv; Eravirenz; 154598-52-4;(4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,
    1-benzoxazin-2-one; Stocrin; zoxazin-2-one;
  • CAS Registry Number:
  • Transport: OTH
  • Density: 1.53 g/cm3
  • Refractive index: 1.58
  • Molecular Weight: 315.67497
  • InchiKey: XPOQHMRABVBWPR-ZDUSSCGKSA-N
  • InChI: InChI=1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,
    21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1
  • Molecular Formula: C14H9ClF3NO2
  • Molecular Structure:CAS No:154598-52-4 (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,<br />1-benzoxazin-2-one

Related products

Search by region :

Select to

154598-52-4 EFAVIRENZ

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong null,nullHong kong
Contact Supplier

154598-52-4 200093 (S)-6-CHLORO-4-(CYCLOPROPYLETHYNYL)-4-(TRIFLUOROMETHYL)-1H-BENZO[D][1,3]OXAZIN-2(4H)-ONE EFAVIRENZ

  • Germany chemcube UG [Manufacturer]
  • Tel: +49 (22 08) 7 75 04 06
  • Fax: +49 (22 08) 7 75 02 30 /
    +49 (32 12) 1 00 74 76
  • Address: chemcube UG
    Salierweg 1
    53859 Niederkassel
    Germany null,nullGermany
Contact Supplier

154598-52-4 EFAVIRENZ

Contact Supplier

154598-52-4 EFAVIRENZ

  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany null,nullGermany
Contact Supplier

154598-52-4 Efavirnez

  • Efavirnez
  • China Sunkingchem Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-28-88007744
  • Fax: +86-28-85193812
  • Address: A-703, Gaofa Building, Jiuxing Road 6#, Hi-Tech Zone 610041, Chengdu, Sichuan, China.610041 ChengduCHINA Chengdu,nullChina
Contact Supplier

154598-52-4 Efavirenz

  • Efavirenz, 99.0%Min
  • China Zeniview Chemistry Technology Co., Ltd. [Manufacturer]
  • Tel: +86-25-86088590
  • Fax: +86-25-85612276
  • Address: No.05,No.01 Hangzhongmen Dajie, Nanjing, China 210016 Nanjing CHINA 210016 NanjingCHINA Nanjing,nullChina
Contact Supplier

154598-52-4 Efavirenz

  • Efavirenz, 99%
  • China Suzhou Rovathin Foreign Trade Co.,Ltd [Manufacturer]
  • Tel: 86-512-65816829/ 86-512-61978430
  • Fax: 86-512-65816839
  • Address: Suzhou Rovathin Foreign Trade Co.,Ltd
    (Sales Company of Affiliated Plant in China)
    Room 603, 327 of ShiZi Street,
    Suzhou, Jiangsu, China 215006 null,nullChina
Contact Supplier

154598-52-4 Efavirenz

  • Efavirenz, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
Contact Supplier

154598-52-4 EFAVIRENZ

Contact Supplier

154598-52-4 EFAVIRENZ

  • China YiPeng Chemical [Manufacturers]
  • Tel: 571 85376369
  • Fax: 571 88233092
  • Address: Building 4,High-tech Industrial Park,No. 588 Feijiatang Road,Xiacheng District, Hangzhou, China null,ZheJiangChina
Contact Supplier

Select to

1/7
1 2 3 4 5 6 7 Next
References of (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,
1-benzoxazin-2-one
Title: Efavirenz
CAS Registry Number: 154598-52-4
CAS Name: (4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
Manufacturers' Codes: DMP-266
Trademarks: Stocrin (Merck & Co.); Sustiva (BMS)
Molecular Formula: C14H9ClF3NO2
Molecular Weight: 315.67
Percent Composition: C 53.27%, H 2.87%, Cl 11.23%, F 18.06%, N 4.44%, O 10.14%
Literature References: Nonnucleoside HIV-1 reverse transcriptase inhibitor. Prepn: S. D. Young et al., EP 582455; eidem, US 5519021 (1994, 1996 both to Merck & Co.). Pharmacology: S. D. Young et al., Antimicrob. Agents Chemother. 39, 2602 (1995). Enantioselective synthesis: A. S. Thompson et al., Tetrahedron Lett. 36, 8937 (1995). Total synthesis and resolution of enantiomers: L. A. Radesca et al., Synth. Commun. 27, 4373 (1997). Ionization behavior: S. R. Rabel et al., Pharm. Dev. Technol. 1, 91 (1996). Clinical trial as component of combination therapy in HIV-1 infection in adults: S. Staszewski et al., N. Engl. J. Med. 341, 1865 (1999); in children: S. E. Starr et al., ibid. 1874. Review of clinical experience: C. Fortin, V. Joly, Expert Rev. Anti Infect. Ther. 2, 671-684 (2004).
Properties: Crystals from toluene:heptane, mp 139-141°. [a]D20 -84.7° (c = 0.005 g/ml in CH3Cl). [a]D25 -94.1° (c = 0.300 in methanol). pKa 10.2.
Melting point: mp 139-141°
pKa: pKa 10.2
Optical Rotation: [a]D20 -84.7° (c = 0.005 g/ml in CH3Cl); [a]D25 -94.1° (c = 0.300 in methanol)
Therap-Cat: Antiviral.
Keywords: Antiviral; Reverse Transcriptase Inhibitor.