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CAS No 14930-96-2 , Cytochalasin B

  • Name: Cytochalasin B
  • Synonyms: (7S),(20R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E),21(E)-triene-1,23-dione;Cytochalasin B;
  • CAS Registry Number:
  • Transport: UN 1544
  • Melting Point: 218-223 ºC
  • Density: 1.2 g/cm3
  • Refractive index: 1.596
  • Water Solubility: ethanol: 20 mg/mL in water
  • Safety Statements: R26/27/28;R63
  • Hazard Symbols: T+: Very toxic;
  • EINECS: 239-000-2
  • Molecular Weight: 479.61
  • InChI: InChI=1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24?,26?,27-,29-/m1/s1
  • Risk Statements: S28;S36/37;S45
  • Molecular Formula: C29H37NO5
  • Molecular Structure:CAS No:14930-96-2 Cytochalasin B
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14930-96-2 Cytochalasin B

  • Cytochalasin B
  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany null,nullGermany
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14930-96-2 Cytochalasin B

  • China Chemrio International Limited [Manufacturer]
  • Tel: +86 574 2789 1268/ +86-139 5789 5864 (mobile)
  • Fax: +86 574 2789 1266
  • Address: Chemrio International Limited
    Room 611-612, Wante Business Center
    No.487 Yangmuqi Road,
    Hi-tech Park Ningbo, 315040,China null,nullChina
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14930-96-2 CYTOCHALASIN B

  • Germany Cfm Oskar Tropitzsch [Manufacturer]
  • Tel: +49-9231-9619-0
  • Fax: +49-9231-9619-60
  • Address: Cfm Oskar Tropitzsch
    Waldershofer Str. 49-51
    95615 Marktredwitz
    Germany null,nullGermany
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14930-96-2 CYTOCHALASIN B(RG)

  • CYTOCHALASIN B(RG)
  • United States ChromaDex Inc. [Manufacturer]
  • Tel: 949-419-0288
  • Fax: 949-419-0294
  • Address: ChromaDex Inc.
    10005 Muirlands Blvd. Suite G - First Floor
    Irvine, CA 92618 null,nullUnited States
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14930-96-2 Cytochalasin B

  • Cytochalasin B, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
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14930-96-2 Cytochalasin B

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14930-96-2 Cytochalasin B

  • Cytochalasin B
  • Germany IRIS Biotech GmbH [Manufacturer]
  • Tel: +49 9231 9619 73
  • Fax: +49 9231 9619 99
  • Address: IRIS Biotech GmbH
    Waldershofer Str. 49-51
    D-95615 Marktredwitz, Germany null,nullGermany
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14930-96-2 cytochalasin B, 99%

  • cytochalasin B, 99%
  • China Pleapharma Co.,Ltd [Manufacturer]
  • Tel: 86 23 67030808
  • Fax: 86 23 67030809
  • Address: 22F,Jingxin center,No.70 Xingguang Road,Yubei Zone,Chongqing402232 chongqingCHINA chongqing,nullChina
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14930-96-2 Cytochalasin B, Helminthosporium dematioideum, > 97 %

  • Cytochalasin B, Helminthosporium dematioideum, > 97 %
  • United Kingdom Fluorochem Ltd. [Importer/Exporter]
  • Tel: (01457) 868921 (4 lines)
  • Fax: (01457) 869360/860927
  • Address: Wesley Street, Old Glossop, Derbyshire SK13 7RY Old Glossop,DerbyshireUnited Kingdom
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References of Cytochalasin B
Title: Cytochalasins
Literature References: A class of mold metabolites exhibiting a number of unusual and varied effects on animal cells. More than twenty cytochalasins are known, isolated from several different mold spp. All are characterized by a highly substituted hydrogenated isoindole ring of known configuration to which is fused a macrocyclic ring. This ring may vary from 11 to 14 atoms in size and may be either a carbocycle or a lactone. Isoln and structure of cytochalasins A, B, C, D: Aldridge et al., J. Chem. Soc. C 1967, 1667; eidem, Chem. Commun. 1967, 26; of E and F: Aldridge et al., ibid. 1972, 148. Revised structures of cytochalasins E and F: Aldridge et al., ibid. 1973, 551; Büchi et al., J. Am. Chem. Soc. 95, 5423 (1973). Isoln of H, also known as paspaline-P or kodocytochalasin-1: G. S. Pendse, Experientia 30, 107 (1974). Structure of H: S. A Patwardhan et al., Phytochemistry 13, 1985 (1974); M. A. Beno et al., J. Am. Chem. Soc. 99, 4123 (1977); x-ray crystal and molecular structure: J. A. McMillan et al., Chem. Commun. 1977, 105. Isoln of K, L, M from Chalara microspora and proposed structures: T. Fex, Tetrahedron Lett. 22, 2703 (1981). Isoln of E and K from Aspergillus clavatus and proposed alternate structure of K: P. S. Steyn et al., J. Chem. Soc. Perkin Trans. 1 1982, 541. Partial synthesis of A and B: S. Masamune et al., J. Am. Chem. Soc. 99, 6756 (1977). Total synthesis of B: G. Stork et al., ibid. 100, 7775 (1978). Major biological effects are the blockage of cytoplasmic cleavage by blocking formation of contractile microfilament structures, resulting in multinucleate cell formation, the reversible inhibition of cell movement, and the induction of nuclear extrusion: Carter, Nature 213, 261 (1967); Krishan, J. Cell Biol. 54, 657 (1972); E. D. Korn, Physiol. Rev. 62, 703 (1982). Correlation between effects of cytochalasins on cellular structures and cellular events and those on actin in vitro: I. Yahara et al., J. Cell Biol. 92, 69 (1982). Other reported effects include the inhibition of glucose transport, of thyroid secretion, of growth hormone release, of phagocytosis, and of platelet aggregation and clot contraction. See D. A. Hume et al., Nature 272, 359 (1978). Nomenclature: M. Binder et al., J. Chem. Soc. Perkin Trans. 1 1973, 1146. Reviews: M. Binder, C. Tamm, Angew. Chem. Int. Ed. 12, 370 (1973); R. B. Herbert in The Alkaloids vol. 7, J. E. Saxton, Ed. (The Chemical Society, London, 1977) pp 29-30; W. G. Thilly et al., Front. Biol. 46, 53-64 (1978); L. V. Domnina et al., Proc. Natl. Acad. Sci. USA 79, 7754-7757 (1982); W. Siess et al., ibid. 7709-7713.
 
Derivative Type: Cytochalasin B
CAS Registry Number: 14930-96-2
CAS Name: (7S,13E,16R,20R,21E)-7,20-Dihydroxy-16-methyl-10-phenyl-24-oxo[14]cytochalasa-6(12),13,21-triene-1,23-dione
Synonyms: (E,E)-16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-2H-oxacyclotetradec[2,3-d]isoindole-2,18(5H)-dione; phomin
Molecular Formula: C29H37NO5
Molecular Weight: 479.61
Percent Composition: C 72.62%, H 7.78%, N 2.92%, O 16.68%
Literature References: The most important and biologically studied of the cytochalasins. Formerly isolated from cultures of a Phoma sp. and called phomin: Rothweiler, Tamm, Experientia 22, 750 (1966). Physicochemical data: A. E. Pohland et al., Pure Appl. Chem. 54, 2219 (1982).
Properties: Felted needles from acetone, mp 218-221°. Completely stable under normal conditions. Solutions in DMSO show no decrease in potency when stored at 4° for three years (Aldrich data sheet). Solubility (mg/ml at 24°): acetone 10.3; ethanol 35.4; DMSO 371; DMF 492. Insol in water.
Melting point: mp 218-221°
 
Use: As tools in cytological research and in characterization of polymerization properties of actin, q.v.