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CAS No 148-18-5 , sodium

  • Name: sodium
  • Synonyms: Na-ddtc; Nocceler SDC; Thiocarb; SODIUM DIETHYLDITHIOCARBAMATE; 148-18-5;N,N-diethylcarbamodithioate; Dithiocarb; Kupral; Imuthiol;sodium; Cupral;Ditiocarb sodium;
  • CAS Registry Number:
  • Melting Point: 95 ºC
  • Flash Point: 60.5°C
  • Boiling Point: 176.4°Cat760mmHg
  • Density: 1.086g/cm3
  • Water Solubility: >=10 G/100 ML AT 14 ºC
  • Safety Statements: Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic and teratogenic data. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NOx, SOx, and Na2O. Used as a pesticide. See also CARBAMATES.
  • Flash Point: 60.5°C
  • EINECS: 205-710-6
  • Molecular Weight: 171.259369
  • InchiKey: IOEJYZSZYUROLN-UHFFFAOYSA-M
  • InChI: InChI=1S/C5H11NS2.Na/c1-3-6(4-2)5(7)8;/h3-4H2,1-2H3,(H,7,8);/q;+1/p-1
  • Molecular Formula: C5H10NNaS2
  • Molecular Structure:CAS No:148-18-5 sodium

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References of sodium
Title: Ditiocarb Sodium
CAS Registry Number: 148-18-5
CAS Name: Diethylcarbamodithioic acid sodium salt
Synonyms: diethyldithiocarbamic acid sodium salt; diethyldithiocarbamate sodium; dithiocarb; DTC; DDC; DEDC; DDTC; DeDTC
Trademarks: Imuthiol
Molecular Formula: C5H10NNaS2
Molecular Weight: 171.26
Percent Composition: C 35.07%, H 5.89%, N 8.18%, Na 13.42%, S 37.45%
Line Formula: (C2H5)2NCS2Na
Literature References: Chelating agent with strong affinity for Hg, Cu, Ni and Zn. Also active as T-cell specific immunostimulant. Prepn: A. M. Clifford, J. G. Lichty, J. Am. Chem. Soc. 54, 1163 (1932); A. L. Klebanskii, L. P. Fomina, Zh. Obshch. Khim. 30, 794 (1960). Absorption spectrum: H. P. Koch, J. Chem. Soc. 1949, 401. Inhibition of superoxide dismutase in mice: R. E. Heikkila et al., J. Biol. Chem. 251, 2182 (1976); of cisplatin nephrotoxicity in rats: R. F. Borch et al., Proc. Natl. Acad. Sci. USA 77, 5441 (1980). Clinical use in acute nickel carbonyl poisoning: F. W. Sunderman, F. W. Sunderman Jr., Am. J. Med. Sci. 236, 26 (1958); F. W. Sunderman, Ann. Clin. Lab. Sci. 9, 1 (1979); in acute cadmium poisoning: G. R. Gale et al., ibid. 11, 476 (1981) and 13, 207 (1983). Specific effects on T-cell regulation: A. Pompidou et al., Int. J. Immunopharmacol. 7, 561 (1985). Clinical evaluation in T-cell deficient diseases: E. Lemarie et al., Methods Find. Exp. Clin. Pharmacol. 8, 51 (1986); in AIDS-related complex: A. Pompidou et al., Comp. Immunol. Microbiol. Infect. Dis. 9, 263 (1986). Review of pharmacology, toxicity and clinical uses: G. Renoux, J. Pharmacol. 13, Suppl. 1, 95-134 (1982); of immunopharmacology and use in cancer immunotherapy: G. Renoux et al., Adv. Exp. Med. Biol. 166, 223-239 (1983).
 
Derivative Type: Trihydrate
Molecular Formula: C5H10NNaS2.3H2O
Molecular Weight: 225.31
Percent Composition: C 26.65%, H 7.16%, N 6.22%, Na 10.20%, S 28.46%, O 21.30%
Properties: Thin, irregular plate-like crystals from acetone, mp 94-102°. Also reported as 90-92° (Sunderman, Sunderman). Freely sol in water; sol in ethanol, methanol, acetone. Insol in ether, benzene. The aq soln is alkaline to litmus and phenolphthalein and slowly dec. (pH of 10% aq soln is 11.6 at room temp). The addition of an acid to the aq soln produces a white turbidity due to the liberation of carbon disulfide. uv max (ethanol): 257, 290 nm (e 1200, 13000). LD50 orally in rats, mice: 2830, 1870 mg/kg; i.v. in mice: >1000 mg/kg (Renoux, 1982).
Melting point: mp 94-102°
Absorption maximum: uv max (ethanol): 257, 290 nm (e 1200, 13000)
Toxicity data: LD50 orally in rats, mice: 2830, 1870 mg/kg; i.v. in mice: >1000 mg/kg (Renoux, 1982)
 
Use: For colorimetric determination of small quantities of copper and for its separation from other metals.
Therap-Cat: Immunomodulator. Chelating agent (copper); Wilson's Disease treatment. Antidote (nickel, cadmium poisoning).
Keywords: Antidote (Heavy Metal Poisoning); Chelating Agent; Immunomodulator; Wilson's Disease Treatment.