Home > Name List By 4 > 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2- ylpyrimidin-4-yl]benzenesulfonamide

CAS No 147536-97-8 , 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-
ylpyrimidin-4-yl]benzenesulfonamide

  • Name: 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-
    ylpyrimidin-4-yl]benzenesulfonamide
  • Synonyms: 147536-97-8; Ro-47-0203; CHEBI:51450;Tracleer; Ro 47-0203; Actelion; Bosentan hydrate; Bosentan (INN); bosentanum;4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-
    ylpyrimidin-4-yl]benzenesulfonamide;
  • CAS Registry Number:
  • Melting Point: 195 ºC
  • Flash Point: 402.8 ºC
  • Boiling Point: 742.3 ºC at 760 mmHg
  • Density: 1.326 g/cm3
  • Refractive index: 1.607
  • Safety Statements: Experimental reproductive effects. When heated to decomposition it emits toxic vapors of NOx and SOx.
  • Flash Point: 402.8 ºC
  • Molecular Weight: 551.61406
  • InchiKey: GJPICJJJRGTNOD-UHFFFAOYSA-N
  • InChI: InChI=1S/C27H29N5O6S/c1-27(2,3)18-10-12-19(13-11-18)39(34,
    35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-
    14-7-15-29-24/h5-15,33H,16-17H2,1-4H3,(H,30,31,32)
  • Molecular Formula: C27H29N5O6S
  • Molecular Structure:CAS No:147536-97-8 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-<br />ylpyrimidin-4-yl]benzenesulfonamide

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References of 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-
ylpyrimidin-4-yl]benzenesulfonamide
Title: Bosentan
CAS Registry Number: 147536-97-8
CAS Name: 4-(1,1-Dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2￠-bipyrimidin]-4-yl]benzenesulfonamide
Synonyms: p-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide
Manufacturers' Codes: Ro-47-0203
Molecular Formula: C27H29N5O6S
Molecular Weight: 551.61
Percent Composition: C 58.79%, H 5.30%, N 12.70%, O 17.40%, S 5.81%
Literature References: Mixed endothelin receptor antagonist. Prepn: K. Burri et al., CA 2071193; eidem, US 5292740 (1992, 1994 both to Hoffmann-La Roche). Receptor binding study: M. Clozel et al., J. Pharmacol. Exp. Ther. 270, 228 (1994). LC-MS determn in plasma: B. Lausecker, G. Hopfgartner, J. Chromatogr. A 712, 75 (1995). Clinical pharmacology: G. Sütsch et al., Cardiovasc. Drugs Ther. 10, 717 (1996). Clinical pharmacokinetics: C. Weber et al., Clin. Pharmacol. Ther. 60, 124 (1996). Clinical trial in hypertension: H. Krum et al., N. Engl. J. Med. 338, 784 (1998); in pulmonary arterial hypertension: L. J. Rubin et al., ibid. 346, 896 (2002).
 
Derivative Type: Monohydrate
CAS Registry Number: 157212-55-0
Trademarks: Tracleer (Actelion)
Molecular Formula: C27H29N5O6S.H2O
Molecular Weight: 569.63
Percent Composition: C 56.93%, H 5.49%, N 12.29%, O 19.66%, S 5.63%
Properties: White to yellowish powder. Soly (mg/100 ml): water 1.0; aq soln 0.1 (pH 1.1); 0.1 (pH 4.0); 0.2 (pH 5.0); 43 (pH 7.5).
 
Derivative Type: Sodium salt
CAS Registry Number: 150726-52-6
Molecular Formula: C27H28N5NaO6S
Molecular Weight: 573.60
Percent Composition: C 56.54%, H 4.92%, N 12.21%, Na 4.01%, O 16.74%, S 5.59%
Properties: mp 195-198°.
Melting point: mp 195-198°
 
Therap-Cat: Antihypertensive.
Keywords: Endothelin Receptor Antagonist; Antihypertensive.