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CAS No 14698-29-4 , 5-ethyl-8-oxo-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid

  • Name: 5-ethyl-8-oxo-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid
  • Synonyms: Dioxacin; Nidantin; Gramurin; Oksaren;Emyrenil; Oxolinic; Utibid;5-ethyl-8-oxo-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid; 14698-29-4; Prodoxol;
  • CAS Registry Number:
  • Transport: 25kgs
  • Density: 1.483 g/cm3
  • Refractive index: 1.638
  • Water Solubility: Insoluble
  • Safety Statements: R22
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 238-750-8
  • Molecular Weight: 261.23014
  • InchiKey: KYGZCKSPAKDVKC-UHFFFAOYSA-N
  • InChI: InChI=1S/C13H11NO5/c1-2-14-5-8(13(16)17)12(15)7-3-10-11(4-9(7)14)19-6-
    18-10/h3-5H,2,6H2,1H3,(H,16,17)
  • Risk Statements: S22;S24/25
  • Molecular Formula: C13H11NO5
  • Molecular Structure:CAS No:14698-29-4 5-ethyl-8-oxo-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid

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References of 5-ethyl-8-oxo-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid
Title: Oxolinic Acid
CAS Registry Number: 14698-29-4
CAS Name: 5-Ethyl-5,8-dihydro-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid
Synonyms: 1-ethyl-1,4-dihydro-6,7-methylenedioxy-4-oxo-3-quinolinecarboxylic acid; 1-ethyl-6,7-methylenedioxy-4-quinolone-3-carboxylic acid
Manufacturers' Codes: W-4565
Trademarks: Inoxyl (Debat); Nidantin (Warner-Lambert); Uritrate (Warner-Lambert); Urotrate (Warner-Lambert)
Molecular Formula: C13H11NO5
Molecular Weight: 261.23
Percent Composition: C 59.77%, H 4.24%, N 5.36%, O 30.62%
Literature References: Quinolone antibacterial. Prepn: Kaminsky, Meltzer, US 3287458 (1966 to Warner-Lambert); eidem, J. Med. Chem. 11, 160 (1968). Pharmacology: Turner et al., Antimicrob. Agents Chemother. 1967, 475 sqq. Metabolism studies: DiCarlo et al., Arch. Biochem. Biophys. 127, 503 (1968); Crew et al., Xenobiotica 1, 193 (1971). Use in urinary tract infections: S. Kalowski et al., Med. J. Aust. 21, 345 (1979); E. Anza et al., Minerva Med. 70, 2333 (1979). Mechanism of action study: H. T. Wright et al., Science 213, 455 (1981). Brief review of therapeutic use: R. Glickman et al., Am. J. Hosp. Pharm. 36, 1077-1079 (1979).
Properties: Crystals from DMF, mp 314-316° (dec). LD50 in mice, rats (mg/kg): >6000, >2000 orally (Turner).
Melting point: mp 314-316° (dec)
Toxicity data: LD50 in mice, rats (mg/kg): >6000, >2000 orally (Turner)
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Synthetic); Quinolones and Analogs.