Home > Name List By other > (2S)-1-[(4R,7S,10S,13S,16S, 19R)-19-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]-7-(2- amino-2-oxoethyl)-10-(3-am... China

CAS No 14636-12-5 , (2S)-1-[(4R,7S,10S,13S,16S,
19R)-19-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]-7-(2-
amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-
hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,
17-pentazacycloicosane-4-carbonyl]-N-[(2S)-6-amino-1-[(2-amino-2-
oxoethyl)amino]-1-oxohexan-2-yl]pyrrolidine-2-carboxamide Search by region : China

  • Name: (2S)-1-[(4R,7S,10S,13S,16S,
    19R)-19-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]-7-(2-
    amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-
    hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,
    17-pentazacycloicosane-4-carbonyl]-N-[(2S)-6-amino-1-[(2-amino-2-
    oxoethyl)amino]-1-oxohexan-2-yl]pyrrolidine-2-carboxamide
  • Synonyms: Lucassin; Terlipressinum [INN-Latin]; Terlipressina [INN-Spanish]; Terlipressine; Terlipressine [INN-French]; Terlipressina;(2S)-1-[(4R,7S,10S,13S,16S,
    19R)-19-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]-7-(2-
    amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-
    hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,
    17-pentazacycloicosane-4-carbonyl]-N-[(2S)-6-amino-1-[(2-amino-2-
    oxoethyl)amino]-1-oxohexan-2-yl]pyrrolidine-2-carboxamide;glypressin;
  • CAS Registry Number:
  • Density: 1.46 g/cm3
  • Refractive index: 1.664
  • EINECS: 238-680-8
  • Molecular Weight: 1227.37216
  • InchiKey: BENFXAYNYRLAIU-QSVFAHTRSA-N
  • InChI: InChI=1S/C52H74N16O15S2/c53-17-5-4-9-31(45(76)60-23-41(57)72)63-51(82)
    38-10-6-18-68(38)52(83)37-27-85-84-26-36(61-44(75)25-59-43(74)24-58-42
    (73)22-54)50(81)65-34(20-29-11-13-30(69)14-12-29)48(79)64-33(19-28-7-2-
    1-3-8-28)47(78)62-32(15-16-39(55)70)46(77)66-35(21-40(56)71)49(80)67-37/
    h1-3,7-8,11-14,31-38,69H,4-6,9-10,15-27,53-54H2,(H2,55,70)(H2,56,71)(H2,
    57,72)(H,58,73)(H,59,74)(H,60,76)(H,61,75)(H,62,78)(H,63,82)(H,64,79)(H,
    65,81)(H,66,77)(H,67,80)/t31-,32-,33-,34-,35-,36-,37-,38-/m0/s1
  • Molecular Formula: C52H74N16O15S2
  • Molecular Structure:CAS No:14636-12-5 (2S)-1-[(4R,7S,10S,13S,16S,<br />19R)-19-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]-7-(2-<br />amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-<br />hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,<br />17-pentazacycloicosane-4-carbonyl]-N-[(2S)-6-amino-1-[(2-amino-2-<br />oxoethyl)amino]-1-oxohexan-2-yl]pyrrolidine-2-carboxamide

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    References of (2S)-1-[(4R,7S,10S,13S,16S,
    19R)-19-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]-7-(2-
    amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-
    hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,
    17-pentazacycloicosane-4-carbonyl]-N-[(2S)-6-amino-1-[(2-amino-2-
    oxoethyl)amino]-1-oxohexan-2-yl]pyrrolidine-2-carboxamide
    Title: Terlipressin
    CAS Registry Number: 14636-12-5
    CAS Name: N-[N-(N-Glycylglycyl)glycyl]-8-L-lysinevasopressin
    Synonyms: Na-glycylglycylglycylvasopressin; 1-triglycyl-8-lysinevasopressin
    Trademarks: Glypressin (Ferring)
    Molecular Formula: C52H74N16O15S2
    Molecular Weight: 1227.37
    Percent Composition: C 50.89%, H 6.08%, N 18.26%, O 19.55%, S 5.22%
    Literature References: Analog of lypressin, q.v. Prepn: E. Kasafirek et al., Collect. Czech. Chem. Commun. 31, 4581 (1966); Z. Procházka et al., ibid. 43, 1285 (1978). Pharmacological studies: J. Kyncl et al., Eur. J. Pharmacol. 28, 294 (1974); P. O. B. Sj?quist et al., Acta Pharmacol. Toxicol. 40, 369 (1977). Use in treatment of uterine bleeding: V. Pavlin et al., Br. J. Obstet. Gynaecol. 85, 801 (1978). Hemostatic effects in cirrhosis patients: C. V. Prowse et al., Eur. J. Clin. Invest. 10, 49 (1980). Conversion to lysine vasopressin in man: M. L. Forsling et al., J. Endocrinol. 85, 237 (1980). Uterine effects in first trimester of pregnancy: T. Laudanski, M. Aakerlund, Contraception 22, 199 (1980). Single-dose effects on renal potassium excretion in humans: H. Nadvornikova, O. Schueck, Int. J. Clin. Pharmacol. Ther. Toxicol. 20, 155 (1982).
     
    Derivative Type: Diacetate pentahydrate
    Trademarks: Glycylpressin (Ferring)
    Molecular Formula: C56H82N16O19S2.5H2O
    Molecular Weight: 1437.55
    Percent Composition: C 46.79%, H 6.45%, N 15.59%, O 26.71%, S 4.46%
    Properties: [a]D25 -82° (c = 0.2 in 1M acetic acid).
    Optical Rotation: [a]D25 -82° (c = 0.2 in 1M acetic acid)
     
    Therap-Cat: Vasopressor (treatment of uterine and esophogeal bleeding).
    Keywords: Antidiuretic.