References of 4-(1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl)-2-benzyl-4-oxobutanoic acid
Title: Mitiglinide
CAS Registry Number: 145375-43-5
CAS Name: (a
S,3a
R,7a
S)-Octahydro-g-oxo-a-(phenylmethyl)-2
H-isoindole-2-butanoic acid
Synonyms: (2
S)-2-benzyl-3-(
cis-hexahydroisoindolin-2-ylcarbonyl)propionic acid
Molecular Formula: C19H25NO3
Molecular Weight: 315.41
Percent Composition: C 72.35%, H 7.99%, N 4.44%, O 15.22%
Literature References: Hypoglycemic agent for treatment of type 2 diabetes. Prepn: F. Sato
et al., EP 507534;
eidem, US 5202335 (1992, 1993 both to Kissei); T. Yamaguchi
et al., Chem. Pharm. Bull. 45, 1518 (1997);
eidem, ibid. 46, 337 (1998). Improved synthesis: J. Liu
et al., Helv. Chim. Acta 87, 1935 (2004). 2D-NMR conformation study: L. Lins
et al., Biochem. Pharmacol. 52, 1155 (1996). Mechanism of action studies: F. Reimann
et al., Br. J. Pharmacol. 132, 1542 (2001); N. Kaiser
et al., ibid. 146, 872 (2005). Clinical evaluation in type 2 diabetes: R. Assaloni
et al., Diabetologia 48, 1919 (2005).
Properties: Viscous oil. [a]D24 -3.2° (c = 1.04 in methanol); [a]D18 -3.5° (c = 1.00 in methanol).
Optical Rotation: [a]D24 -3.2° (c = 1.04 in methanol); [a]D18 -3.5° (c = 1.00 in methanol)
Derivative Type: Calcium salt dihydrate
CAS Registry Number: 207844-01-7; 145525-41-3 (anhydrous)
Manufacturers' Codes: KAD-1229; S-21403
Trademarks: Glufast (Kissei)
Molecular Formula: C38H48CaN2O6.2H2O
Molecular Weight: 704.91
Percent Composition: C 64.75%, H 7.44%, Ca 5.69%, N 3.97%, O 18.16%
Properties: Colorless crystals from 5% aqueous ethanol, mp 179-185° C. [a]D18 +5.7° (c = 1.0 in methanol).
Melting point: mp 179-185° C
Optical Rotation: [a]D18 +5.7° (c = 1.0 in methanol)
Therap-Cat: Antidiabetic.
Keywords: Antidiabetic.