Home > Name List By a > Acetic acid,2-[[1-[(2S)-2-[[4-(aminoiminomethyl)benzoyl]amino]-3-(4-hydroxyphenyl)-1-oxopropyl]-4-piperidinyl]oxy]-

CAS No 144412-49-7 , Acetic acid,2-[[1-[(2S)-2-[[4-(aminoiminomethyl)benzoyl]amino]-3-(4-hydroxyphenyl)-1-oxopropyl]-4-piperidinyl]oxy]-

  • Name: Acetic acid,2-[[1-[(2S)-2-[[4-(aminoiminomethyl)benzoyl]amino]-3-(4-hydroxyphenyl)-1-oxopropyl]-4-piperidinyl]oxy]-
  • Synonyms: Lamifiban; Ro 44-9883/000; Acetic acid,[[1-[2-[[4-(aminoiminomethyl)benzoyl]amino]-3-(4-hydroxyphenyl)-1-oxopropyl]-4-piperidinyl]oxy]-,(S)-;Acetic acid,2-[[1-[(2S)-2-[[4-(aminoiminomethyl)benzoyl]amino]-3-(4-hydroxyphenyl)-1-oxopropyl]-4-piperidinyl]oxy]-; Ro 44-9883;Aceticacid, [[1-[(2S)-2-[[4-(aminoiminomethyl)benzoyl]amino]-3-(4-hydroxyphenyl)-1-oxopropyl]-4-piperidinyl]oxy]-(9CI);
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.39g/cm3
  • Refractive index: 1.648
  • Flash Point: °C
  • Molecular Weight: 0
  • InChI: InChI=1/C24H28N4O6/c25-22(26)16-3-5-17(6-4-16)23(32)27-20(13-15-1-7-18(29)8-2-15)24(33)28-11-9-19(10-12-28)34-14-21(30)31/h1-8,19-20,29H,9-14H2,(H3,25,26)(H,27,32)(H,30,31)/t20-/m0/s1
  • Molecular Formula: C24H28 N4 O6
  • Molecular Structure:CAS No:144412-49-7 Acetic acid,2-[[1-[(2S)-2-[[4-(aminoiminomethyl)benzoyl]amino]-3-(4-hydroxyphenyl)-1-oxopropyl]-4-piperidinyl]oxy]-

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References of Acetic acid,2-[[1-[(2S)-2-[[4-(aminoiminomethyl)benzoyl]amino]-3-(4-hydroxyphenyl)-1-oxopropyl]-4-piperidinyl]oxy]-
Title: Lamifiban
CAS Registry Number: 144412-49-7
CAS Name: (S)-[[1-[2-[[4-(Aminoiminomethyl)benzoyl]amino]-3-(4-hydroxyphenyl)-1-oxopropyl]-4-piperidinyl]oxy]acetic acid
Synonyms: [[1-[N-(p-amidinobenzoyl)-L-tyrosyl]-4-piperidinyl]oxy]acetic acid
Manufacturers' Codes: Ro-44-9883
Molecular Formula: C24H28N4O6
Molecular Weight: 468.50
Percent Composition: C 61.53%, H 6.02%, N 11.96%, O 20.49%
Literature References: Specific nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist. Prepn: L. Alig et al., EP 505868; eidem, US 5378712 (1992, 1995 both to Hoffmann-La Roche); L. Alig et al., J. Med. Chem. 35, 4393 (1992). Pharmacology: J.-P. Carteaux et al., Thromb. Haemostasis 70, 817 (1993); Y. Takiguchi et al., ibid. 73, 683 (1995).
Properties: Crystals (zwitterionic form) from water, mp above 200° (dec). [a]D20 +29.8° (c = 0.86 in 1N HCl).
Melting point: mp above 200° (dec)
Optical Rotation: [a]D20 +29.8° (c = 0.86 in 1N HCl)
 
Derivative Type: Trifluoroacetate salt
CAS Registry Number: 144412-50-0
Molecular Formula: C24H28N4O6.C2HF3O2
Molecular Weight: 582.53
Percent Composition: C 53.61%, H 5.02%, N 9.62%, O 21.97%, F 9.78%
Properties: mp 125-130° (dec). LD50 i.v. in mice: 250 mg/kg (Alig, 1995).
Melting point: mp 125-130° (dec)
Toxicity data: LD50 i.v. in mice: 250 mg/kg (Alig, 1995)
 
Therap-Cat: Antithrombotic.
Keywords: Antithrombotic; Fibrinogen Receptor Antagonist.