Home > Name List By other > (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4, 6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S, 6S)-3-amino-6-(am...

CAS No 1404-04-2 , (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,
6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,
6S)-3-amino-6-(aminomethyl)-4,
5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-
hydroxycyclohexyl]oxyoxane-3,4-diol

  • Name: (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,
    6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,
    6S)-3-amino-6-(aminomethyl)-4,
    5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-
    hydroxycyclohexyl]oxyoxane-3,4-diol
  • Synonyms: Soframycin; Actiline; Actilin; Soframycine; Fradiomycin;neomycin; Mycifradin; Framycetin;(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,
    6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,
    6S)-3-amino-6-(aminomethyl)-4,
    5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-
    hydroxycyclohexyl]oxyoxane-3,4-diol; Antibiotique; NEOMYCIN B;
  • CAS Registry Number:
  • Flash Point: 586.5°C
  • Boiling Point: 1046.1°C at 760 mmHg
  • Density: 1.61 g/cm3
  • Safety Statements: Poison by intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic by ingestion. Human systemic effects: changes in hearing acuity, liver tubule changes, and decreased urine volume or anuria. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 586.5°C
  • EINECS: 215-773-1
  • Molecular Weight: 614.64374
  • InchiKey: PGBHMTALBVVCIT-VCIWKGPPSA-N
  • InChI: InChI=1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5
    (26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-
    25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,
    15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
  • Risk Statements: 42/43
  • Molecular Formula: C23H46N6O13
  • Molecular Structure:CAS No:1404-04-2 (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,<br />6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,<br />6S)-3-amino-6-(aminomethyl)-4,<br />5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-<br />hydroxycyclohexyl]oxyoxane-3,4-diol

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References of (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,
6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,
6S)-3-amino-6-(aminomethyl)-4,
5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-
hydroxycyclohexyl]oxyoxane-3,4-diol
Title: Neomycin
CAS Registry Number: 1404-04-2
Trademarks: Mycifradin (Upjohn); Fradiomycin; Neomin; Neolate; Neomas; Pimavecort (Mycofarm); Vonamycin Powder V
Literature References: Antibiotic complex composed of neomycins A, B and C. Produced by Streptomyces fradiae: Waksman, Lechevalier, Science 109, 305 (1949); Waksman et al., J. Clin. Invest. 28, 934 (1949); Swart et al., ibid. 1045; Waksman, Lechevalier, US 2799620 (1957). Purification: Jackson, US 2848365 (1958 to Upjohn); Haak, US 3108996 (1963 to Upjohn). Recovery: Miller, US 3005815 (1961 to Merck & Co.); Moses, US 3022228 (1962 to Penick); GB 945475 (1964 to O.W.G. Chemie). Characterization: Peck et al., J. Am. Chem. Soc. 71, 2590 (1949); Regna, Murphy, ibid. 72, 1045 (1950); Dutcher et al., ibid. 73, 1384 (1951). Structure of neomycins B and C: K. L. Rinehart et al., ibid. 79, 4567, 4568 (1957); ibid. 84, 3216, 3218 (1962). Abs config of neomycin C: M. Hichens, K. L. Rinehart, ibid. 85, 1547 (1963). Total synthesis of neomycin C: S. Umewaza, Y. Nishimura, J. Antibiot. 30, 189 (1977); S. Umewaza et al., Bull. Chem. Soc. Jpn. 53, 3259 (1980); of neomycin B: T. Usui, S. Umezawa, J. Antibiot. 40, 1464 (1987). Monographs: S. A. Waksman, Neomycin (Rutgers Univ. Press, New Brunswick, N. J., 1953) 219 pp; K. L. Rinehart, Jr., The Neomycins and Related Antibiotics (Wiley, New York, 1964) 137 pp. Comprehensive description: W. F. Heyes, Anal. Profiles Drug Subs. 8, 399-488 (1979).
Properties: Neomycin complex is an amorphous base sol in water, methanol and acidified alcohol. Practically insol in common organic solvents. Solns up to 250 mg/ml H2O may be prepared.
 
Derivative Type: Neomycin A see Neamine
 
Derivative Type: Neomycin B
CAS Registry Number: 119-04-0
Synonyms: Antibiotique EF 185; framycetin
Trademarks: Enterfram; Framygen; Actilin
Molecular Formula: C23H46N6O13
Molecular Weight: 614.64
Percent Composition: C 44.94%, H 7.54%, N 13.67%, O 33.84%
Properties: Identity of neomycin B and framycetin: K. L. Rinehart et al., ibid. 82, 3938 (1960). Yields on hydrolysis neamine and neobiosamine B. Structure of neobiosamine B: K. L. Rinehart et al., J. Am. Chem. Soc. 82, 2970 (1960).
 
Derivative Type: Neomycin B hydrochloride
CAS Registry Number: 25389-99-5
Properties: Amorphous white powder. [a]D20 +57° (H2O). Soly in mg/ml at ~28°: water 15.0; methanol 5.7; ethanol 0.65; isopropanol 0.05; isoamyl alcohol 0.33; cyclohexane 0.06; benzene 0.03. Practically insol in acetone, ether, other organic solvents. For additional soly data see Weiss et al., Antibiot. Chemother. 7, 374 (1957).
Optical Rotation: [a]D20 +57° (H2O)
 
Derivative Type: Neomycin B sulfate
CAS Registry Number: 1405-10-3
Trademarks: Biosol (Biokema); Bykomycin (Byk Gulden); Endomixin (Lusofarmaco); Fraquinol; Myacine; Neosulf; Neomix (Tuco); Neobrettin (Norbrook); Nivemycin (Boots); Soframycin (HMR); Tuttomycin
Properties: Amorphous white powder. Practically tasteless. [a]D20 +54° (c = 2 in H2O). Soly in mg/ml at ~28°: water 6.3; methanol 0.225; ethanol 0.095; isopropanol 0.082; isoamyl alcohol, 0.247; cyclohexane 0.08; benzene 0.05. Practically insol in acetone, ether, chloroform. Aq solns are fairly stable at pH 2 to 9. Highly purified prepns are very stable to alkali and unstable to acids. Refluxing with barium hydroxide for 18 hrs showed no loss of activity. Boiling with mineral acids yields an aldehyde, characterized as furfural, and an organic base.
Optical Rotation: [a]D20 +54° (c = 2 in H2O)
 
Derivative Type: Neomycin C
CAS Registry Number: 66-86-4
Molecular Formula: C23H46N6O13
Molecular Weight: 614.64
Percent Composition: C 44.94%, H 7.54%, N 13.67%, O 33.84%
Properties: Yields on hydrolysis neamine and neobiosamine C. Structure of neobiosamine C: K. L. Rinehart, P. Woo, J. Am. Chem. Soc. 80, 6463 (1958).
 
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Antibiotics); Aminoglycosides.