References of 2-azido-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
Title: Azidamfenicol
CAS Registry Number: 13838-08-9
CAS Name: 2-Azido-
N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide
Synonyms: D-(-)-
threo-1-
p-nitrophenyl-2-azidoacetylaminopropane-1,3-diol; D-(-)-
threo-2-azidoacetamido-1-
p-nitrophenyl-1,3-propanediol; azidoamphenicol
Trademarks: Berlicetin (Chauvin ankerpharm); Leukomycin-N (Bayer); Posifenicol (Ursapharm); Thilocanfol (Alcon)
Molecular Formula: C11H13N5O5
Molecular Weight: 295.25
Percent Composition: C 44.75%, H 4.44%, N 23.72%, O 27.09%
Literature References: Semi-synthetic antibiotic related to chloramphenicol,
q.v. Prepn: Meiser, Domagk,
US 2882275 (1959 to Bayer).
Properties: Crystals from ethylene chloride, mp 107°. [a]D20 -20° (c = 1.6 in ethyl acetate). pH 7.1. Sol in water up to 2%.
Melting point: mp 107°
Optical Rotation: [a]D20 -20° (c = 1.6 in ethyl acetate)
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); Amphenicols.