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CAS No 134308-13-7 , (3,4-dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone

  • Name: (3,4-dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone
  • Synonyms: Tasmar; 134308-13-7;(3,4-dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone; Ro-40-7592; Ro 40-7592; 3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone;
  • CAS Registry Number:
  • Melting Point: 126-1280C
  • Flash Point: 485.6°Cat760mmHg
  • Boiling Point: 485.6°Cat760mmHg
  • Density: 1.419g/cm3
  • Refractive index: 1.661
  • Flash Point: 485.6°Cat760mmHg
  • Molecular Weight: 273.24084
  • InchiKey: MIQPIUSUKVNLNT-UHFFFAOYSA-N
  • InChI: InChI=1S/C14H11NO5/c1-8-2-4-9(5-3-8)13(17)10-6-11(15(19)20)14(18)12(16)
    7-10/h2-7,16,18H,1H3
  • Molecular Formula: C14H11NO5
  • Molecular Structure:CAS No:134308-13-7 (3,4-dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone

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References of (3,4-dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone
Title: Tolcapone
CAS Registry Number: 134308-13-7
CAS Name: (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
Synonyms: 3,4-dihydroxy-4￠-methyl-5-nitrobenzophenone
Manufacturers' Codes: Ro-40-7592
Trademarks: Tasmar (Valeant)
Molecular Formula: C14H11NO5
Molecular Weight: 273.24
Percent Composition: C 61.54%, H 4.06%, N 5.13%, O 29.28%
Literature References: Orally active inhibitor of central and peripheral catechol-O-methyltransferase (COMT). Prepn: K. Bernauer et al., EP 237929; eidem, US 5236952 (1987, 1993 both to Hoffmann-La Roche). Pharmacology: G. Zürcher et al., Adv. Neurol. 53, 497 (1990). HPLC determn in plasma: U. Timm, R. Erdin, J. Chromatogr. 593, 63 (1992). Clinical pharmacokinetics: J. Dingemanse et al., Clin. Pharmacol. Ther. 57, 508 (1995). Clinical evaluation as adjunct to levodopa: P. Limousin et al., Clin. Neuropharmacol. 18, 258 (1995). Review of pharmacology and clinical experience: G. M. Keating, K. A. Lyseng-Williamson, CNS Drugs 19, 165-184 (2005); of safety and efficacy: N. Borges, Expert Opin. Drug Saf. 4, 69-73 (2005).
Properties: Crystals from methylene chloride, mp 146-148°.
Melting point: mp 146-148°
Therap-Cat: Antiparkinsonian.
Keywords: Antiparkinsonian; COMT Inhibitor.