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CAS No 13392-28-4 , 1-(1-adamantyl)ethanamine

  • Name: 1-(1-adamantyl)ethanamine
  • Synonyms: 1-(1-Adamantyl)ethanamine; Rimant; Rimantadina; Rimantadinum; 13392-28-4; Riamantadine;Flumadine;1-(1-adamantyl)ethanamine; Remantadine;
  • CAS Registry Number:
  • Density: 1.033
  • Refractive index: 1.539
  • Molecular Weight: 179.30184
  • InchiKey: UBCHPRBFMUDMNC-UHFFFAOYSA-N
  • InChI: InChI=1S/C12H21N/c1-8(13)12-5-9-2-10(6-12)4-11(3-9)7-12/h8-11H,2-7,13H2,
    1H3
  • Molecular Formula: C12H21N
  • Molecular Structure:CAS No:13392-28-4 1-(1-adamantyl)ethanamine

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References of 1-(1-adamantyl)ethanamine
Title: Rimantadine
CAS Registry Number: 13392-28-4
CAS Name: a-Methyltricyclo[3.3.1.13,7]decane-1-methanamine
Synonyms: a-methyl-1-adamantanemethylamine; remantadin(e)
Molecular Formula: C12H21N
Molecular Weight: 179.30
Percent Composition: C 80.38%, H 11.81%, N 7.81%
Literature References: Deriv of adamantane, q.v. Prepn: NL 6408505; W. W. Prichard, US 3352912 (1965, 1967 both to du Pont). Antiviral activity: A. Tsunoda et al., Antimicrob. Agents Chemother. 1965, 553. Effects on influenza in mice: J. W. McGahen et al., Ann. N.Y. Acad. Sci. 173, 557 (1970). Mechanism of action study: A. Bukrinskaya et al., Arch. Virol. 66, 275 (1980); eidem, J. Gen. Virol. 60, 49 (1982). Pharmacokinetics in humans: R. J. Wills et al., Antimicrob. Agents Chemother. 31, 826 (1987). Clinical trial in prophylaxis of influenza A infection: R. Dolin et al., N. Engl. J. Med. 307, 580 (1982). Comparative toxicity of rimantadine and amantadine in healthy adults: F. G. Hayden et al., Antimicrob. Agents Chemother. 19, 226 (1981). Controlled study of CNS effects: V. M. Millet et al., ibid. 21, 1 (1982). Review of studies in the USSR on exptl and clinical pharmacology: D. M. Zlydnikov et al., Rev. Infect. Dis. 3, 408-421 (1981).
 
Derivative Type: Hydrochloride
CAS Registry Number: 1501-84-4
Manufacturers' Codes: EXP-126
Trademarks: Flumadine (Roche); Meradan(e) (USSR); Roflual (Roche)
Molecular Formula: C12H21N.HCl
Molecular Weight: 215.76
Percent Composition: C 66.80%, H 10.28%, N 6.49%, Cl 16.43%
Properties: White crystals, mp 373-375° (sealed tube).
Melting point: mp 373-375° (sealed tube)
 
Therap-Cat: Antiviral.
Keywords: Antiviral.