CAS No 131179-95-8 , 2-[4-[2-(3,5-dimethylanilino)-2-oxoethyl]phenoxy]-2-methylpropanoic acid

Name: 2-[4-[2-(3,5-dimethylanilino)-2-oxoethyl]phenoxy]-2-methylpropanoic acid
Synonyms: 2-(4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy)-2-methylpropionic acid; 2-Dacmpp;Efaproxyn; Rsr 13; 131179-95-8;2-[4-[2-(3,5-dimethylanilino)-2-oxoethyl]phenoxy]-2-methylpropanoic acid; RSR13;
CAS Registry Number:131179-95-8
Flash Point: 289.2°C
Boiling Point: 554.5°Cat760mmHg
Density: 1.202g/cm³
Refractive index: 1.597
Flash Point: 289.2°C
Molecular Weight: 341.40092
InchiKey: BNFRJXLZYUTIII-UHFFFAOYSA-N
InChI: InChI=1S/C20H23NO4/c1-13-9-14(2)11-16(10-13)21-18(22)12-15-5-7-17(8-6-
15)25-20(3,4)19(23)24/h5-11H,12H2,1-4H3,(H,21,22)(H,23,24)
Molecular Formula: C₂₀H₂₃NO₄
Molecular Structure:

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References of 2-[4-[2-(3,5-dimethylanilino)-2-oxoethyl]phenoxy]-2-methylpropanoic acid

Title: Efaproxiral
CAS Registry Number: 131179-95-8
CAS Name: 2-[4-[2-[(3,5-Dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methylpropanoic acid
Synonyms: 2-4-[[(3,5-dimethylanilino)carbonyl]methyl]phenoxy-2-methylpropionic acid
Manufacturers' Codes: RSR-13
Molecular Formula: C20H23NO4
Molecular Weight: 341.40
Percent Composition: C 70.36%, H 6.79%, N 4.10%, O 18.75%
Literature References: Allosteric modifier of hemoglobin (Hb). Binds in the central water cavity of the Hb molecule causing a conformational change such that bound oxygen is released more readily. Prepd not claimed: D. J. Abraham et al., US 5049695 (1991 to Center Innovative Technol.); eidem., J. Med. Chem. 34, 752 (1991). Oxygen binding affinities and mechanism of action: D. J. Abraham et al., Biochemistry 31, 9141 (1992). Effect on myocardial oxygen concentration: P. S. Pagel et al., J. Pharmacol. Exp. Ther. 285, 1 (1998). Antimetastatic effects: B. A. Teicher et al., Cancer Chemother. Pharmacol. 42, 24 (1998). Clinical pharmacokinetics and pharmacodynamics: L. Kleinberg et al., J. Clin. Oncol. 17, 2593 (1999). Clinical evaluation in brain tumor therapy: eidem, ibid. 20, 3149 (2002).
Properties: mp 85°.
Melting point: mp 85°
Therap-Cat: Antineoplastic adjunct (radiosensitizer).
Keywords: Antineoplastic Adjunct; Radiosensitizer.