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CAS No 130636-43-0 , 1-(3,4-dichlorophenyl)-3-hexylurea

  • Name: 1-(3,4-dichlorophenyl)-3-hexylurea
  • Synonyms: AC1Q3OIV;ST50202734; NSC108144; 13041-39-9;1-(3,4-dichlorophenyl)-3-hexylurea; CTK4B6704; 130636-43-0; KST-1B0151; MolPort-002-051-010; AC1L6JI1;
  • CAS Registry Number:
  • Melting Point: 117.5-118.5ºC
  • Density: 1.32 g/cm3
  • Molecular Weight: 289.20082
  • InchiKey: XTRZVEIMQUXRBC-UHFFFAOYSA-N
  • InChI: InChI=1S/C13H18Cl2N2O/c1-2-3-4-5-8-16-13(18)17-10-6-7-11(14)12(15)9-10/
    h6-7,9H,2-5,8H2,1H3,(H2,16,17,18)
  • Molecular Formula: C13H18Cl2N2O
  • Molecular Structure:CAS No:130636-43-0 1-(3,4-dichlorophenyl)-3-hexylurea

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References of 1-(3,4-dichlorophenyl)-3-hexylurea
Title: Nifekalant
CAS Registry Number: 130636-43-0
CAS Name: 6-[[2-[(2-Hydroxyethyl)[3-(4-nitrophenyl)propyl]amino]ethyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione
Molecular Formula: C19H27N5O5
Molecular Weight: 405.45
Percent Composition: C 56.28%, H 6.71%, N 17.27%, O 19.73%
Literature References: Nonselective potassium channel blocker. Prepn: T. Katakami et al., EP 369627; eidem, US 5008267 (1990, 1991 both to Mitsui Toatsu Chem.); eidem, J. Med. Chem. 35, 3325 (1992). Pharmacology: J. Kamiya et al., Drug Dev. Res. 30, 37 (1993). Clinical experience: M. Igawa et al., J. Cardiovasc. Pharmacol. 40, 735 (2002); T. Minami et al., Pacing Clin. Electrophysiol. 27, 212 (2004). Review of pharmacology: H. Nakaya, H. Uemura, Cardiovasc. Drug Rev. 16, 133-144 (1998); of development and therapeutic potential: A. Zaza, Curr. Opin. Cardiovasc. Pulm. Renal Invest. Drugs 2, 86-94 (2000). Clinical evaluation in ventricular tachyarrhythmias: T. Katoh et al., Circ. J. 69, 1237 (2005); T. Washizuka et al., ibid. 1508; in shock-refractory ventricular fibrillation: Y. Tahara et al., ibid. 70, 442 (2006).
Properties: Crystals from ethanol, mp 117.5-118.5°. Also reported as mp 125-126° (Katakami, 1992).
Melting point: mp 117.5-118.5°; mp 125-126° (Katakami, 1992)
 
Derivative Type: Hydrochloride
CAS Registry Number: 130656-51-8
Manufacturers' Codes: MS-551
Trademarks: Shinbit (Nihon Schering)
Molecular Formula: C19H27N5O5.HCl
Molecular Weight: 441.91
Percent Composition: C 51.64%, H 6.39%, N 15.85%, O 18.10%, Cl 8.02%
Properties: Light yellow to yellow crystals from methanol, mp 172-174°. Very sol in water, slightly sol in methanol, very slightly sol in ethanol. Practically insol in ether. pH 4.0 - 5.5 (5 mg/ml saline soln). pKa 7.05.
Melting point: mp 172-174°
pKa: pKa 7.05
 
Therap-Cat: Antiarrhythmic (class III).
Keywords: Antiarrhythmic; Potassium Channel Blocker.