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CAS No 129791-92-0 , Rifalazil

  • Name: Rifalazil
  • Synonyms: 3'-Hydroxy-5'-(4-isobutylpiperazinyl)benzoxazinorifamycin;Rifalazil; 5,12-Dihydroxy-2,4-dimethyl-10-[4-(2-methyl-propyl)-l-piperazinyl]-2,7-[oxy(5-acetoxy-7,9-dihydroxy-3-methoxy-4,6,8,10,14-pentamethyl-15-oxo-l,ll,13-pentadecatriene-l,15-diyl)imino]-6H-benzofuro[4,5-a]phenoxazine-l(2H),6-dione;
  • CAS Registry Number:
  • Flash Point: 588°C
  • Boiling Point: 1048.6°Cat760mmHg
  • Density: 1.36g/cm3
  • Refractive index: 1.634
  • Flash Point: 588°C
  • Molecular Weight: 941.08
  • InChI: InChI=1/C51H64N4O13/c1-24(2)23-54-16-18-55(19-17-54)32-21-33(57)39-35(22-32)67-48-40(52-39)36-37-44(60)30(8)47-38(36)49(62)51(10,68-47)65-20-15-34(64-11)27(5)46(66-31(9)56)29(7)43(59)28(6)42(58)25(3)13-12-14-26(4)50(63)53-41(48)45(37)61/h12-15,20-22,24-25,27-29,34,42-43,46,52,57-60H,16-19,23H2,1-11H3/b13-12+,20-15+,26-14-,53-41+/t25-,27-,28+,29-,34-,42-,43-,46+,51-/m0/s1
  • Molecular Formula: C51H64N4O13
  • Molecular Structure:CAS No:129791-92-0 Rifalazil

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129791-92-0 rifalazil

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References of Rifalazil
Title: Rifalazil
CAS Registry Number: 129791-92-0
CAS Name: 1￠,4-Didehydro-1-deoxy-1,4-dihydro-3￠-hydroxy-5￠-[4-(2-methylpropyl)-1-piperazinyl]-1-oxorifamycin VIII
Synonyms: (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-5,12,21,23,25-pentahydroxy-10-(4-isobutyl-1-piperazinyl)-27-methoxy-2,4,16,20,22,24,26-heptamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)-6H-benzofuro[4,5-a]phenoxazine-1(2H),6,15-trione 25-acetate; 3￠-hydroxy-5￠-(4-isobutyl-1-piperazinyl)benzoxazinorifamycin
Manufacturers' Codes: KRM-1648
Molecular Formula: C51H64N4O13
Molecular Weight: 941.07
Percent Composition: C 65.09%, H 6.85%, N 5.95%, O 22.10%
Literature References: Semisynthetic derivative of rifamycin S, q.v. Prepn: T. Yamane et al., EP 366914; eidem, US 4983602 (1990, 1991 both to Kanegafuchi); eidem, Chem. Pharm. Bull. 41, 148 (1993). Antimycobacterial efficacy in comparison with rifampin, q.v.: T. Yamamoto et al., Antimicrob. Agents Chemother. 40, 426 (1996). Pharmacokinetics: K. Hosoe et al., ibid. 2749. HPLC determn in biological fluids: eidem, J. Chromatogr. B 653, 177 (1994). Review of pharmacology and clinical studies: D. M. Rothstein et al., Expert Opin. Invest. Drugs 12, 255-271 (2003).
Properties: Crystals from chloroform-hexane, mp 195-200° (dec).
Melting point: mp 195-200° (dec)
Therap-Cat: Antibacterial (tuberculostatic).
Keywords: Antibacterial (Tuberculostatic).