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CAS No 129-46-4 , hexasodium

  • Name: hexasodium
  • Synonyms: Suramin hexasodium; Suramina sodica [INN-Spanish]; Naphuride sodium; SURAMIN SODIUM; Naganinum;8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,
    8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]
    carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,
    5-trisulfonate; Suramin sodium salt; Fourneau 309; Suramine sodium salt;hexasodium;
  • CAS Registry Number:
  • Melting Point: 1429.17
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: g/cm3
  • Safety Statements: S24/25
  • Flash Point: °C
  • EINECS: 204-949-3
  • Molecular Weight: 1429.170676
  • InchiKey: VAPNKLKDKUDFHK-UHFFFAOYSA-H
  • InChI: InChI=1S/C51H40N6O23S6.6Na/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,
    70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,
    76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)
    48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,
    73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80;;;;;;/h3-24H,
    1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,
    66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,
    80);;;;;;/q;6*+1/p-6
  • Risk Statements: S24/25
  • Molecular Formula: C51H34N6Na6O23S6
  • Molecular Structure:CAS No:129-46-4 hexasodium

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129-46-4 SURAMIN HEXASODIUM SALT

  • Germany BIOTREND Chemikalien GmbH [Manufacturer]
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129-46-4 Suramin Sodium

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129-46-4 SURAMIN HEXASODIUM SALT(RG)

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129-46-4 1,3,5-Naphthalenetrisulfonicacid,8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-,sodium salt (1:6)

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129-46-4 SC-200833 SURAMIN SODIUM

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129-46-4 SURAMIN

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129-46-4 1472 SURAMIN HEXASODIUM SALT

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129-46-4 Suramin Sodium

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129-46-4 Suramin Sodium

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References of hexasodium
Title: Suramin Sodium
CAS Registry Number: 129-46-4
CAS Name: 8,8￠-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
Synonyms: hexasodium sym-bis(m-aminobenzoyl-m-amino-p-methylbenzoyl-1-naphthylamino-4,6,8-trisulfonate) carbamide
Manufacturers' Codes: Bayer 205; Fourneau 309
Trademarks: Antrypol (AstraZeneca); Germanin (Bayer); Moranyl (Specia); Naganol; Naphuride
Molecular Formula: C51H34N6Na6O23S6
Molecular Weight: 1429.17
Percent Composition: C 42.86%, H 2.40%, N 5.88%, Na 9.65%, O 25.75%, S 13.46%
Literature References: Discovered in 1917 by O. Dressel and R. Kothe: J. Dressel, J. Chem. Educ. 38, 620 (1961). Prepn: E. Fourneau et al., Compt. Rend. 178, 675 (1924); J. Trefouel, E. Fourneau, GB 224849 (1923); B. Heymann, Angew. Chem. 37, 585 (1924). Pharmacology, toxicology and clinical antiparasitic activity: F. Hawking, Adv. Pharmacol. Chemother. 15, 289-322 (1978). Inhibition of reverse transcriptase in vitro: E. De Clercq, Cancer Lett. 8, 9 (1979); vs HIV: H. Mitsuya et al., Science 226, 172 (1984). HPLC determn in plasma: R. W. Klecker, J. M. Collins, J. Liq. Chromatogr. 8, 1685 (1985). Pharmacokinetics: J. M. Collins et al., J. Clin. Pharmacol. 26, 22 (1986). Pharmacology and virustatic effect in AIDS: S. Broder et al., Lancet 2, 627 (1985); A. M. Levine et al., Ann. Intern. Med. 105, 32 (1986). Clinical trial in onchocerciasis: H. Schultz-Key et al., Trop. Med. Parasitol. 36, 244 (1985); in prostate cancer: C. Myers et al., J. Clin. Oncol. 10, 881 (1992). Review: Olenick in Antibiotics vol. 3, J. W. Corcoran, F. E. Hahn, Eds. (Springer-Verlag, New York, 1975) pp 699-703; R. La Rocca et al., Cancer Cells 2, 106-115 (1990).
Properties: White or slightly pink or cream-colored powder. Slightly bitter taste. Hygroscopic. Freely sol in water, in physiological saline; sparingly sol in 95% alcohol. Insol in benzene, ether, petr ether, chloroform. Aq solns are neutral to litmus. LD50 in mice (mg/kg): ~620 i.v. (Hawking).
Toxicity data: LD50 in mice (mg/kg): ~620 i.v. (Hawking)
Therap-Cat: Anthelmintic (Nematodes); antiprotozoal (Trypanosoma).
Therap-Cat-Vet: Antiprotozoal (Trypanosoma).
Keywords: Anthelmintic (Nematodes); Antiprotozoal (Trypanosoma); Reverse Transcriptase Inhibitor.