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CAS No 12758-40-6 , 3-[[2-carboxyethyl(oxo)germyl]oxy-oxogermyl]propanoic acid

  • Name: 3-[[2-carboxyethyl(oxo)germyl]oxy-oxogermyl]propanoic acid
  • Synonyms: Carboxyethylgermanium sesquioxide; 14C-Proxigermanium;3-[[2-carboxyethyl(oxo)germyl]oxy-oxogermyl]propanoic acid; 2-Carboxyethylgermasesquioxane; Ge 132;Propagermanium;
  • CAS Registry Number:
  • Safety Statements: Moderately toxic by intravenous route. Experimental reproductive effects. See also GERMANIUM COMPOUNDS.
  • EINECS: 235-800-0
  • Molecular Weight: 339.4194
  • InchiKey: XEABSBMNTNXEJM-UHFFFAOYSA-N
  • InChI: InChI=1S/C6H10Ge2O7/c9-5(10)1-3-7(13)15-8(14)4-2-6(11)12/h1-4H2,(H,9,
    10)(H,11,12)
  • Risk Statements: 36/37/38
  • Molecular Formula: C6H10Ge2O7
  • Molecular Structure:CAS No:12758-40-6 3-[[2-carboxyethyl(oxo)germyl]oxy-oxogermyl]propanoic acid
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12758-40-6 CARBOXYETHYLGERMANIUM SESQUIOXIDE; 95%

  • Germany ABCR GmbH & Co KG [Manufacturer]
  • Tel: +49 721 95061-0
  • Fax: +49 721 95061-80
  • Address: Im Schlehert 10
    76187 Karlsruhe
    Germany null,nullGermany
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12758-40-6 BIS(CARBOXYETHYLGERMANIUM) SESQUIOXIDE, 99.7%

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong null,nullHong kong
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12758-40-6 Bis(2-carboxyethylgermanium sesquioxide)

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 null,nullUnited States
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12758-40-6 Bis(2-carboxyethylgermanium sesquioxide)

  • China Hangzhou Sage Chemical Co., Ltd. [Manufacturer]
  • Tel: +86-571-86818502
  • Fax: +86-571-86818503
  • Address: RM501 Tower A, New Youth Plaza, NO.8 Jia Shan Road, Hangzhou, Zhejiang 310014, null,ZhejiangChina
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12758-40-6 Bis(2-carboxyethylgermanium sesquioxide)

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12758-40-6 Bis(2-carboxyethylgermanium sesquioxide)

  • China Haihang Industry Co., Ltd. null
  • Tel: +86-(531)-88032799
  • Fax: +86-(531)-85821093
  • Address: 2/F, East Tower, Bldg 12, No. 2 Qilihe Road, Jinan 250100, null,nullChina
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12758-40-6 Bis(2-carboxyethylgermanium sesquioxide)

  • United States Parchem Trading [Manufacturer]
  • Tel: 914.654.6800
  • Fax: 914.654.6899
  • Address: Parchem Trading Ltd.
    415 Huguenot Street
    New Rochelle, NY 10801 null,nullUnited States
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12758-40-6 Bis(2-carboxyethylgermanium sesquioxide)

  • China Shanghai Xunxin Chemical Co., Ltd [Manufacturers]
  • Tel: +86-(21)-38218795
  • Fax: +86-(21)-38218795
  • Address: 580 Lane, Kanghong Road, Pudong New District, Shanghai 201315, Shanghai,ShanghaiChina
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12758-40-6 Bis(2-carboxyethylgermanium sesquioxide)

  • China Laiwu Hehui Chemical Co.,Ltd. null
  • Tel: +86-(531)-88772589
  • Fax: +86-(531)-88772589
  • Address: Huashan Rd., Jinan City, Shandong 250000, null,nullChina
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12758-40-6 GERMANIUM SESQUIOXIDE USP

  • United States Carbomer, Inc. [Manufacturer]
  • Tel: 858-552-0992/ (800) 239-7129
  • Fax: 858-552-0999
  • Address: PO Box 261026-1026
    San Diego, CA 92196 null,nullUnited States
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References of 3-[[2-carboxyethyl(oxo)germyl]oxy-oxogermyl]propanoic acid
Title: Propagermanium
CAS Registry Number: 12758-40-6
CAS Name: 3,3¢-(1,3-Dioxo-1,3-digermoxanediyl)bispropanioic acid
Synonyms: 2-(carboxyethyl)germanium sesquioxide; 3-oxygermylpropionic acid polymer; poly-trans-[(2-carboxyethyl)germasesquioxane]; proxigermanium; repagermanium
Manufacturers' Codes: GE-132; SK-818
Trademarks: Serocion
Molecular Formula: C6H10Ge2O7
Molecular Weight: 339.42
Percent Composition: C 21.23%, H 2.97%, Ge 42.80%, O 33.00%
Line Formula: (GeCH2CH2COOH)2O3
Literature References: Biologic response modifier. Polymeric organogermanium compound. Orginally synthesized at Asai Germanium Institute in 1967. Prepn and crystal structure: M. Tsutsui et al., J. Am. Chem. Soc. 98, 8287 (1976). Toxicology and clinical pharmacokinetics: K. Miyao et al., Curr. Chemother. Infect. Dis. 2, 1527 (1979). TLC quantitation: X. Peishan et al., J. Planar Chromatogr. Mod. TLC 3, 141 (1990). Electrochemical behavior and determn: K. Hasebe et al., Electroanalysis 6, 779 (1994). Antiviral activity: Y. Ishiwata et al., Arzneim.-Forsch. 44, 357 (1994). Review of biological activities and mechanism of antitumor action: R. R. Brutkiewicz, F. Suzuki, In Vivo 1, 189-204 (1987). Review: K. Miyao, N. Tanaka, Drugs Future 13, 441-453 (1988). Review of clinical use as an immunostimulant: H. Fukazawa et al., Head Neck 16, 30-38 (1994).
Properties: Colorless, monoclinic crystals or crystalline powder having no odour but a slightly acidic taste. mp 270° (dec). pKa 3.6. Sol in water at 1.09% at 20°. Insol or very slightly sol in almost all organic solvents. Very sol in water under alkaline conditions; >10% at pH 7.4. Aq solns exhibit acid reactions. Stable at pH 2-12, especially at pH 7.4 especially where decomposition does not occur at 110° for 5 min. LD50 i.p. in mice: 2.8 g/kg (Brutkiewicz).
Melting point: mp 270° (dec)
pKa: pKa 3.6
Toxicity data: LD50 i.p. in mice: 2.8 g/kg (Brutkiewicz)
Therap-Cat: Antineoplastic; immunostimulant.
Keywords: Antineoplastic; Immunomodulators; Immunomodulator.