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CAS No 127254-12-0 , Sitafloxacin

  • Name: Sitafloxacin
  • Synonyms: spifloxacin;Sitafloxacin;7-[(4S)-4-Amino-6-azaspiro[2.4]heptan-6-yl]-8-chloro-6-fluoro-1-[(2S)-2-fluorocyclopropyl]-4-oxoquinoline-3-carboxylic acid; Sitafloxacin Sesquihydrate; Sitafloxacin hydrate; 7-[(4S)-4-Amino-6-azaspiro[2.4]heptan-6-yl]-8-chloro-6-fluoro-1-[(2S)-2-fluorocyclopropyl]-4-oxoquinoline-3-carboxylic acid;
  • CAS Registry Number:
  • Density: 1.63 g/cm3
  • Refractive index: 1.698
  • Molecular Weight: 409.81
  • InChI: InChI=1/C19H18ClF2N3O3/c20-14-15-8(17(26)9(18(27)28)5-25(15)12-4-10(12)21)3-11(22)16(14)24-6-13(23)19(7-24)1-2-19/h3,5,10,12-13H,1-2,4,6-7,23H2,(H,27,28)/t10-,12-,13+/m0/s1
  • Molecular Formula: C19H18ClF2N3O3
  • Molecular Structure:CAS No:127254-12-0 Sitafloxacin

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127254-12-0 Sitafloxacin

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References of Sitafloxacin
Title: Sitafloxacin
CAS Registry Number: 127254-12-0
CAS Name: 7-[(7S)-7-Amino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
Manufacturers' Codes: DU-6859
Molecular Formula: C19H18ClF2N3O3
Molecular Weight: 409.81
Percent Composition: C 55.69%, H 4.43%, Cl 8.65%, F 9.27%, N 10.25%, O 11.71%
Literature References: Fluorinated quinolone antibacterial. Prepn: I. Hayakawa, Y. Kimura, EP 341493; eidem, US 5587386 (1989, 1996 both to Daiichi); Y. Kimura et al., J. Med. Chem. 37, 3344 (1994). Antibacterial spectrum: L. M. Deshpande, R. N. Jones, Diagn. Microbiol. Infect. Dis. 37, 139 (2000). HPLC determn in serum and urine: H. Aoki et al., J. Chromatogr. B 660, 365 (1994). Clinical pharmacokinetics: M. Nakashima et al., Antimicrob. Agents Chemother. 39, 170 (1995). Clinical evaluation: N. Shetty, A. P. R. Wilson, J. Antimicrob. Chemother. 46, 633 (2000).
 
Derivative Type: Sesquihydrate
CAS Registry Number: 163253-35-8
Manufacturers' Codes: DU-6859a
Properties: Crystals from ethanol, water + ammonium hydroxide, mp 225° (dec). [a]589 -199.9° (c = 1 in 1 N NaOH). Soly in water: 131 mg/ml.
Melting point: mp 225° (dec)
Optical Rotation: [a]589 -199.9°
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Synthetic); Quinolones and Analogs.