Home > Name List By 4 > 4-[[1-[(2S)-3-(2, 3-dihydro-1H-inden-5-yloxy)-2-(2-methoxyethoxymethyl)-3-oxopropyl] cyclopentanecarbonyl]amino]cyclohexane-1...

CAS No 123122-55-4 , 4-[[1-[(2S)-3-(2,
3-dihydro-1H-inden-5-yloxy)-2-(2-methoxyethoxymethyl)-3-oxopropyl]
cyclopentanecarbonyl]amino]cyclohexane-1-carboxylic acid

  • Name: 4-[[1-[(2S)-3-(2,
    3-dihydro-1H-inden-5-yloxy)-2-(2-methoxyethoxymethyl)-3-oxopropyl]
    cyclopentanecarbonyl]amino]cyclohexane-1-carboxylic acid
  • Synonyms: Candoxatril [USAN:INN:BAN]; AC1NSFYL; 123122-55-4; C29H41NO7; CHEBI:288288;4-[[1-[(2S)-3-(2,
    3-dihydro-1H-inden-5-yloxy)-2-(2-methoxyethoxymethyl)-3-oxopropyl]
    cyclopentanecarbonyl]amino]cyclohexane-1-carboxylic acid; DB00616;CHEBI:3353; Candoxatril (JAN/USAN/INN);
  • CAS Registry Number:
  • Flash Point: 388.3°C
  • Boiling Point: 718.4°Cat760mmHg
  • Density: 1.21g/cm3
  • Flash Point: 388.3°C
  • Molecular Weight: 515.63834
  • InchiKey: ZTWZVMIYIIVABD-RZMWZJFBSA-N
  • InChI: InChI=1S/C29H41NO7/c1-35-15-16-36-19-23(27(33)37-25-12-9-20-5-4-6-22(20)
    17-25)18-29(13-2-3-14-29)28(34)30-24-10-7-21(8-11-24)26(31)32/h9,12,17,
    21,23-24H,2-8,10-11,13-16,18-19H2,1H3,(H,30,34)(H,31,32)/t21?,23-,
    24?/m0/s1
  • Molecular Formula: C29H41NO7
  • Molecular Structure:CAS No:123122-55-4 4-[[1-[(2S)-3-(2,<br />3-dihydro-1H-inden-5-yloxy)-2-(2-methoxyethoxymethyl)-3-oxopropyl]<br />cyclopentanecarbonyl]amino]cyclohexane-1-carboxylic acid

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References of 4-[[1-[(2S)-3-(2,
3-dihydro-1H-inden-5-yloxy)-2-(2-methoxyethoxymethyl)-3-oxopropyl]
cyclopentanecarbonyl]amino]cyclohexane-1-carboxylic acid
Title: Candoxatril
CAS Registry Number: 123122-55-4
CAS Name: [4(S)-cis]-4-[[[1-[3-[(2,3-Dihydro-1H-inden-5-yl)oxy]-2-[(2-methoxyethoxy)methyl]-3-oxopropyl]cyclopentyl]carbonyl]amino]cyclohexanecarboxylic acid
Synonyms: (aS)-1-[(cis-4-carboxycyclohexyl)carbamoyl]-a-[(2-methoxyethoxy)methyl]cyclopentanepropionic acid a-5-indanyl ester; (S)-cis-4-[1-[2-(5-indanyloxycarbonyl)-3-(2-methoxyethoxy)propyl]-1-cyclopentanecarboxamido]-1-cyclohexanecarboxylic acid
Manufacturers' Codes: UK-79300
Molecular Formula: C29H41NO7
Molecular Weight: 515.64
Percent Composition: C 67.55%, H 8.01%, N 2.72%, O 21.72%
Literature References: Neutral endopeptidase inhibitor. Prepn: I. T. Barnish et al., EP 274234; eidem, US 5030654 (1988, 1991 both to Pfizer). Enzyme inhibition and pharmacology: J. C. Danilewicz et al., Biochem. Biophys. Res. Commun. 164, 58 (1989). Clinical pharmacokinetics and effect on plasma ANP: J. G. Motwani et al., Clin. Pharmacol. Ther. 54, 661 (1993). Clinical evaluation in congestive heart failure: C. D. Kimmelstiel et al., Cardiology 87, 46 (1996).
Properties: White crystals, mp 107-109°. [a]D -5.8° (c = 1 in methanol).
Melting point: mp 107-109°
Optical Rotation: [a]D -5.8° (c = 1 in methanol)
 
Derivative Type: Diacid
CAS Registry Number: 123122-54-3
Synonyms: Candoxatrilat
Manufacturers' Codes: UK-73967
Molecular Formula: C20H33NO7
Molecular Weight: 399.48
Percent Composition: C 60.13%, H 8.33%, N 3.51%, O 28.04%
Properties: White crystals from ethyl acetate, mp 108.5-109.1°. [a]D +1.4° (c = 1 in methanol).
Melting point: mp 108.5-109.1°
Optical Rotation: [a]D +1.4° (c = 1 in methanol)
 
Therap-Cat: In treatment of congestive heart failure.
Keywords: Neutral Endopeptidase Inhibitor.