Home > Name List By 1 > 1-Azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-, hydrate (1:1),(6R,7S)-

CAS No 121961-22-6 , 1-Azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-, hydrate (1:1),(6R,7S)-

  • Name: 1-Azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-, hydrate (1:1),(6R,7S)-
  • Synonyms: LY 163892 monohydrate; Loracarbef monohydrate;1-Azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-, hydrate (1:1),(6R,7S)-; 1-Azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[[(2R)-aminophenylacetyl]amino]-3-chloro-8-oxo-, monohydrate, (6R,7S)-(9CI);1-Azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[(aminophenylacetyl)amino]-3-chloro-8-oxo-, monohydrate, [6R-[6a,7b(R*)]]-;
  • CAS Registry Number:
  • Density: g/cm3
  • Molecular Weight: 367.7842
  • InChI: InChI=1/C16H16ClN3O4.H2O/c17-9-6-7-10-12(15(22)20(10)13(9)16(23)24)19-14(21)11(18)8-4-2-1-3-5-8;/h1-5,10-12H,6-7,18H2,(H,19,21)(H,23,24);1H2/t10-,11-,12+;/m1./s1
  • Molecular Formula: C16H16 Cl N3 O4 . H2 O
  • Molecular Structure:CAS No:121961-22-6 1-Azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-, hydrate (1:1),(6R,7S)-

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References of 1-Azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-, hydrate (1:1),(6R,7S)-
Title: Loracarbef
CAS Registry Number: 121961-22-6
CAS Name: (6R,7S)-7-[[(2R)-Aminophenylacetyl]amino]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate
Synonyms: (6R,7S)-3-chloro-7-[(R)-phenylglycinamido]-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate; carbacefaclor
Manufacturers' Codes: KT-3777; LY-163892 monohydrate
Trademarks: Lorabid (Lilly)
Molecular Formula: C16H16ClN3O4.H2O
Molecular Weight: 367.78
Percent Composition: C 52.25%, H 4.93%, Cl 9.64%, N 11.43%, O 21.75%
Literature References: Carbacephem analog of cefaclor, q.v. Prepn: T. Hirata et al., EP 14476; eidem, US 4708956 (1980, 1987 both to Kyowa Hakko); I. Matsukuma et al., Chem. Pharm. Bull. 37, 1239 (1989). Prepn of the crystalline monohydrate: C. E. Pasini, EP 311366 (1989 to Lilly). Enantioselective synthesis: C. C. Bodurow et al., Tetrahedron Lett. 30, 2321 (1989). Antibacterial spectrum: K. Sato et al., J. Antibiot. 42, 1844 (1989). b-Lactamase stability: R. N. Jones, A. L. Barry, Eur. J. Clin. Microbiol. 6, 570 (1987). Pharmacology in animals: T. Shetler et al., Arzneim.-Forsch. 43, 60 (1993). Pharmacokinetics in children: J. D. Nelson et al., Antimicrob. Agents Chemother. 32, 1738 (1988).
Properties: mp 205-215° (dec) (Matsukuma). [a]D21 +34.0° (c = 0.35 in water).
Melting point: mp 205-215° (dec) (Matsukuma)
Optical Rotation: [a]D21 +34.0° (c = 0.35 in water)
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Carbacephems.