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CAS No 120210-48-2 , (3Z)-5-chloro-3-[hydroxy(thiophen-2-yl)methylidene]-2-oxoindole-1-
carboxamide

  • Name: (3Z)-5-chloro-3-[hydroxy(thiophen-2-yl)methylidene]-2-oxoindole-1-
    carboxamide
  • Synonyms: Tenidapum;Tenidapum [INN-Latin]; (Z)-5-Chloro-3-(alpha-hydroxy-2-thenylidene)-2-oxo-1-indolinecarboxamide; CHEBI:35847; 120210-48-2;(3Z)-5-chloro-3-[hydroxy(thiophen-2-yl)methylidene]-2-oxoindole-1-
    carboxamide;
  • CAS Registry Number:
  • Melting Point: 320.751
  • Flash Point: 270.7°C
  • Boiling Point: 523.9°Cat760mmHg
  • Density: 1.58g/cm3
  • Refractive index: 1.756
  • Flash Point: 270.7°C
  • Molecular Weight: 320.75086
  • InchiKey: LXIKEPCNDFVJKC-QXMHVHEDSA-N
  • InChI: InChI=1S/C14H9ClN2O3S/c15-7-3-4-9-8(6-7)11(13(19)17(9)14(16)20)12(18)10-
    2-1-5-21-10/h1-6,18H,(H2,16,20)/b12-11-
  • Molecular Formula: C14H9ClN2O3S
  • Molecular Structure:CAS No:120210-48-2 (3Z)-5-chloro-3-[hydroxy(thiophen-2-yl)methylidene]-2-oxoindole-1-<br />carboxamide

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120210-48-2 TENIDAP

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References of (3Z)-5-chloro-3-[hydroxy(thiophen-2-yl)methylidene]-2-oxoindole-1-
carboxamide
Title: Tenidap
CAS Registry Number: 120210-48-2
CAS Name: (Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide
Synonyms: 5-chloro-2,3-dihydro-2-oxo-3-(2-thienylcarbonyl)-1H-indole-1-carboxamide; 5-chloro-3-(2-thenoyl)-2-oxindole-1-carboxamide
Manufacturers' Codes: CP-66248
Molecular Formula: C14H9ClN2O3S
Molecular Weight: 320.75
Percent Composition: C 52.42%, H 2.83%, Cl 11.05%, N 8.73%, O 14.96%, S 10.00%
Literature References: Inhibitor of 5-lipoxygenase and interleukin-1 (IL-1) activity. Prepn: S. B. Kadin, EP 156603; idem, US 4556672 (both 1985 to Pfizer). Effect on 5-lipoxygenase activity in vitro: K. Fogh et al., Arch. Dermatol. Res. 280, 430 (1988). Effect on IL-1 activity in patients with rheumatoid arthritis: B. McDonald et al., Arthritis Rheum. 31, Suppl., S52 (1988). Clinical evaluation: P. Katz et al., ibid. S52.
Properties: Fluffy, yellow crystals from acetic acid, mp 230° (dec).
Melting point: mp 230° (dec)
 
Derivative Type: Sodium salt
CAS Registry Number: 119784-94-0
Manufacturers' Codes: CP-66248-2
Molecular Formula: C14H8ClN2NaO3S
Molecular Weight: 342.73
Percent Composition: C 49.06%, H 2.35%, Cl 10.34%, N 8.17%, Na 6.71%, O 14.00%, S 9.36%
Properties: Crystals from methanol-isopropanol, mp 237-238°.
Melting point: mp 237-238°
 
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); 5-Lipoxygenase Inhibitor.