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CAS No 119356-77-3 , (1S)-N,N-dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine

  • Name: (1S)-N,N-dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine
  • Synonyms: 119356-77-3; Dapoxetina [INN-Spanish];(1S)-N,N-dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine; Dapoxetinum [INN-Latin]; (S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine;
  • CAS Registry Number:
  • Flash Point: 132.6°C
  • Boiling Point: 454.4°Cat760mmHg
  • Density: 1.081 g/cm3
  • Refractive index: 1.607
  • Flash Point: 132.6°C
  • Molecular Weight: 305.41342
  • InchiKey: USRHYDPUVLEVMC-FQEVSTJZSA-N
  • InChI: InChI=1S/C21H23NO/c1-22(2)20(18-10-4-3-5-11-18)15-16-23-21-14-8-12-17-9-
    6-7-13-19(17)21/h3-14,20H,15-16H2,1-2H3/t20-/m0/s1
  • Molecular Formula: C21H23NO
  • Molecular Structure:CAS No:119356-77-3 (1S)-N,N-dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine

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119356-77-3 Dapoxetine

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    References of (1S)-N,N-dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine
    Title: Dapoxetine
    CAS Registry Number: 119356-77-3
    CAS Name: (aS)-N,N-Dimethyl-a-[2-(1-naphthalenyloxy)ethyl]benzenemethanamine
    Synonyms: (+)-N,N-dimethyl-1-phenyl-3-(1-naphthalenyloxy)propanamine
    Manufacturers' Codes: LY-210448
    Molecular Formula: C21H23NO
    Molecular Weight: 305.41
    Percent Composition: C 82.59%, H 7.59%, N 4.59%, O 5.24%
    Literature References: Selective serotonin reuptake inhibitor (SSRI). Prepn: D. W. Robertson et al., EP 288188; eidem, US 5135947 (1988, 1992 both to Lilly). Chiral synthesis: W. J. Wheeler, D. D. O'Bannon, J. Labelled Compd. Radiopharm. 31, 305 (1992). HPLC determn in plasma: C. L. Hamilton, J. D. Cornpropst, J. Chromatogr. 612, 253 (1993). Review of pharmacology and clinical experience: B. Feret, Formulary 40, 227-230 (2005).
     
    Derivative Type: Hydrochloride
    CAS Registry Number: 129938-20-1
    Molecular Formula: C21H23NO.HCl
    Molecular Weight: 341.87
    Percent Composition: C 73.78%, H 7.08%, N 4.10%, O 4.68%, Cl 10.37%
    Properties: White crystalline solid from hydrochloric acid and ethyl acetate. [a]D +135.78° (c = 2.18 in methanol).
    Optical Rotation: [a]D +135.78° (c = 2.18 in methanol)
     
    Therap-Cat: In treatment of premature ejaculation.
    Keywords: Serotonin Uptake Inhibitor.