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CAS No 118-10-5 , Cinchonine

  • Name: Cinchonine
  • Synonyms: Cinchonine;4-Quinolyl(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methanol;
  • CAS Registry Number:
  • Transport: 1544
  • Melting Point: 256-266 ºC
  • Density: 1.2 g/cm3
  • Refractive index: 223 ° (C=0.5, EtOH)
  • Alpha: 224 º (C=0.5, ALCOHOL)
  • Safety Statements: R20/21/22
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 204-234-6
  • Molecular Weight: 294.39
  • InChI: InChI=1/C19H22N2O/c1-2-13-12-21-10-8-14(13)11-18(21)19(22)16-7-9-20-17-6-4-3-5-15(16)17/h2-7,9,13-14,18-19,22H,1,8,10-12H2/t13?,14?,18?,19-/m0/s1
  • Risk Statements: S36/37
  • Molecular Formula: C19H22N2O
  • Molecular Structure:CAS No:118-10-5 Cinchonine
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118-10-5 Cinchonine ;(S)-quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol CAS No. 118-10-5

  • Cinchonine ;(S)-quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol CAS No. 118-10-5 Product Name: Cinchonine Chemical Name: (S)-quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol CAS No. 118-10-5 Synonyms: D-CINCHONINE;(+)-CINCHON...
  • Min. Order: 10
  • China Shanghai Goyic Pharmaceutical &Chemical Co.,Ltd. [Manufacturer]
  • Tel: 86-21-50689757
  • Address: Building 19, No 528, Rui-Qing Road, PuDong New Area, Shanghai, China Shanghai,ShanghaiChina
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118-10-5 Cinchonine solution

  • Cinchonine solution, [FOR SPRAY]
  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong null,nullHong kong
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118-10-5 Cinchonine

  • Cinchonine
  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany null,nullGermany
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118-10-5 Cinchonine

  • China Chemrio International Limited [Manufacturer]
  • Tel: +86 574 2789 1268/ +86-139 5789 5864 (mobile)
  • Fax: +86 574 2789 1266
  • Address: Chemrio International Limited
    Room 611-612, Wante Business Center
    No.487 Yangmuqi Road,
    Hi-tech Park Ningbo, 315040,China null,nullChina
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118-10-5 CINCHONINE

  • United States Bromorganics Corporation [Manufacturer]
  • Tel: 847-238-9588
  • Fax: 847-238-9688
  • Address: Bromorganics Corporation
    P. O. Box 722
    Elk Grove Village, Illinois 60009 null,nullUnited States
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118-10-5 CINCHONINE(RG)

  • CINCHONINE(RG)Cinchonine
  • United States ChromaDex Inc. [Manufacturer]
  • Tel: 949-419-0288
  • Fax: 949-419-0294
  • Address: ChromaDex Inc.
    10005 Muirlands Blvd. Suite G - First Floor
    Irvine, CA 92618 null,nullUnited States
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118-10-5 Cinchonine

  • United States Waterstone Technology LLC [Manufacturer]
  • Tel: 317-644-0862/ 317-218-7464
  • Fax: 317-569-8068
  • Address: Waterstone Technology LLC
    12202 Hancock Street
    Carmel, IN. 46032 null,nullUnited States
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118-10-5 Cinchonine

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118-10-5 Cinchonine

  • China SHANGHAI HANHONG CHEMICAL CO.,LTD. [Manufacturers]
  • Tel: 021-64545202
  • Fax: 021-54291107
  • Address: Room 207, Zenghe Building , No.245, Jiachuan Road, Xuhui District, Shanghai, China shanghai,shanghaiChina
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118-10-5 Cinchonine

  • Cinchonine
  • United States INDOFINE Chemical Co., Inc. [Manufacturer]
  • Tel: (908) 359-6778
  • Fax: (908) 359-1179
  • Address: 121 Stryker Lane
    Bldg 30, Suite 1
    Hillsborough, NJ 08844 null,nullUnited States
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References of Cinchonine
Title: Cinchonine
CAS Registry Number: 118-10-5
CAS Name: (9S)-Cinchonan-9-ol
Molecular Formula: C19H22N2O
Molecular Weight: 294.39
Percent Composition: C 77.52%, H 7.53%, N 9.52%, O 5.43%
Literature References: Occurs in most varieties of cinchona bark, especially in bark of Cinchona micrantha R. & P., Rubiaceae. Isoln and structure: Rabe, Ber. 41, 63 (1908). Stereoisomeric with cinchonidine: Koenigs, Ann. 347, 182 (1906). Configuration: Prelog, Zalán, Helv. Chim. Acta 27, 535 (1944); Prelog, H?fliger, ibid. 33, 2021 (1950); Roth, Pharmazie 16, 257 (1961); Lyle, Keefer, Tetrahedron 23, 3253 (1967). Crystal and molecular structure: B. Oleksyn et al., Acta Crystallogr. B35, 440 (1979). Biosynthetic studies: Battersby, Parry, Chem. Commun. 1971, 31. Toxicity study: C. C. Johnson, C. F. Poe, Acta Pharmacol. Toxicol. 4, 265 (1949).
Properties: Prisms, needles from alcohol or ether. mp about 265°; begins to sublime at 220°. [a]D +229° (alcohol). uv absorption data: Kamath et al., Indian J. Chem. 6, 510 (1968). One gram dissolves in 60 ml alcohol, 25 ml boiling alcohol, 110 ml chloroform, 500 ml ether. Practically insol in water. pK1 5.85, pK2 9.92. Protect from light. LD50 i.p. in rats: 152 mg/kg (Johnson, Poe).
Melting point: mp about 265°
pKa: pK1 5.85, pK2 9.92
Optical Rotation: [a]D +229° (alcohol)
Toxicity data: LD50 i.p. in rats: 152 mg/kg (Johnson, Poe)
 
Derivative Type: Dihydrochloride
Molecular Formula: C19H22N2O.2HCl
Molecular Weight: 367.31
Percent Composition: C 62.13%, H 6.59%, N 7.63%, O 4.36%, Cl 19.30%
Properties: White or faintly yellow crystals or crystalline powder. Freely sol in water or alcohol. Protect from light.
 
Derivative Type: Hydrochloride dihydrate
Molecular Formula: C19H22N2O.HCl.2H2O
Molecular Weight: 366.88
Percent Composition: C 62.20%, H 7.42%, N 7.64%, O 13.08%, Cl 9.66%
Properties: Fine crystals. mp when anhydr about 215° with dec. One gram dissolves in 20 ml water, 3.5 ml boiling water, 1.5 ml alcohol, 20 ml chloroform; slightly sol in ether. The aq soln is practically neutral. Protect from light.
Melting point: mp when anhydr about 215° with dec
 
Derivative Type: Sulfate dihydrate
Molecular Formula: (C19H22N2O)2.H2SO4.2H2O
Molecular Weight: 722.89
Percent Composition: C 63.14%, H 6.97%, N 7.75%, O 17.71%, S 4.44%
Properties: Lustrous, very bitter crystals. mp when anhydr about 198°. One gram dissolves in 65 ml water, 30 ml hot water, 12.5 ml alc, 7 ml hot alc, 47 ml chloroform; slightly sol in ether. The aq soln is practically neutral.
Melting point: mp when anhydr about 198°
 
Derivative Type: Epicinchonine
CAS Registry Number: 485-70-1
CAS Name: (9R)-Cinchonan-9-ol
Properties: mp 83°, [a]D22 +120.3° (c = 0.806 in alc), Rabe et al., Ann. 492, 253 (1932).
Melting point: mp 83°
Optical Rotation: [a]D22 +120.3° (c = 0.806 in alc), Rabe et al., Ann. 492, 253 (1932)
 
Therap-Cat: Antimalarial.
Keywords: Antimalarial.