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CAS No 113-42-8 , Ergoline-8-carboxamide,9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-6-methyl-, (8b)-

  • Name: Ergoline-8-carboxamide,9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-6-methyl-, (8b)-
  • Synonyms: Methylergonovine;Ergoline-8-carboxamide,9,10-didehydro-N-[1-(hydroxymethyl)propyl]-6-methyl-, [8b(S)]-; Methylergobasine;Methylergobrevin; Ergoline-8b-carboxamide,9,10-didehydro-N-[(S)-1-(hydroxymethyl)propyl]-6-methyl- (8CI); Methylergometrine; Methylergometrin;Ergoline-8-carboxamide,9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-6-methyl-, (8b)-; D-Lysergic acid-(+)-1-hydroxy-2-butylamide; Lysergamide,N-[(S)-1-(hydroxymethyl)propyl]- (6CI); Methylergobasin;Partergin; Methergen; Indolo[4,3-fg]quinoline,ergoline-8-carboxamide deriv.;Ergometrine, methyl-; N-[a-(Hydroxymethyl)propyl]-D-lysergamide;
  • CAS Registry Number:
  • Melting Point: 172 DEC C WITH SOME DECOMP
  • Density: 1.28 g/cm3
  • Safety Statements: Poison by ingestion and intravenous routes. When heated to decomposition it emits toxic fumes of NOx.
  • EINECS: 204-027-0
  • Molecular Weight: 0
  • InChI: InChI=1/C20H25N3O2/c1-3-14(11-24)22-20(25)13-7-16-15-5-4-6-17-19(15)12(9-21-17)8-18(16)23(2)10-13/h4-7,9,13-14,18,21,24H,3,8,10-11H2,1-2H3,(H,22,25)/p+1/t13-,14+,18-/m1/s1
  • Molecular Formula: C20H25N3O2
  • Molecular Structure:CAS No:113-42-8 Ergoline-8-carboxamide,9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-6-methyl-, (8b)-

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113-42-8 0549 METHYLERGOMETRINE MALEATE

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113-42-8 Methyl Ergometrine

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References of Ergoline-8-carboxamide,9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-6-methyl-, (8b)-
Title: Methylergonovine
CAS Registry Number: 113-42-8
CAS Name: (8b)-9,10-Didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-6-methylergoline-8-carboxamide
Synonyms: N-[a-(hydroxymethyl)propyl]-D-lysergamide; D-lysergic acid (+)-butanolamide-(2); d-lysergic acid-d-1-hydroxybutylamide-2; methylergometrine; methylergobasine
Molecular Formula: C20H25N3O2
Molecular Weight: 339.43
Percent Composition: C 70.77%, H 7.42%, N 12.38%, O 9.43%
Literature References: Semisynthetic ergot alkaloid; metabolite of methysergide, q.v. Prepn: A. Stoll, A. Hofmann, US 2265207 (1941 to Sandoz); eidem, Helv. Chim. Acta 26, 944 (1943). HPLC determn in plasma: H. T. Smith, N. C. Molinaro, J. Chromatogr. 424, 416 (1988). Clinical trial in prevention of cluster headache: L. Mueller et al., Headache 37, 437 (1997). Review of pharmacology and clinical use in obstetrics and gynecology: A. N. de Groot et al., Drugs 56, 523-535 (1998).
Properties: Shiny crystals from benzene, mp 172° (some decompn). [a]D20 -45° (c = 0.4 in pyridine). Sparingly sol in water. Freely sol in alcohol, acetone.
Melting point: mp 172° (some decompn)
Optical Rotation: [a]D20 -45° (c = 0.4 in pyridine)
 
Derivative Type: Maleate
CAS Registry Number: 57432-61-8
Trademarks: Basofortina (Novartis); Methergin (Novartis); Methergine (Novartis); Metenarin (Teikoku Zoki); Methylergobrevin (Wernigerode); Ryegonovin (Aventis); Spametrin-M (Yamanouchi Seiyaku)
Molecular Formula: C20H25N3O2.C4H4O4
Molecular Weight: 455.50
Percent Composition: C 63.28%, H 6.42%, N 9.23%, O 21.07%
Properties: White to pinkish-tan microcryst powder; odorless; bitter taste. Slightly sol in water, alcohol; very slightly sol in chloroform, ether.
 
Therap-Cat: Oxytocic.
Keywords: Oxytocic.