References of 3H-21,18-Nitrilo-1H,22H-pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetrone,26-[[2-(diethylamino)ethyl]sulfonyl]-8,9,14,15,24,25,26,26a-octahydro-14-hydroxy-4,12-dimethyl-3-(1-methylethyl)-,(3R,4R,5E,10E,12E,14S,26R,26aS)-
Title: Dalfopristin
CAS Registry Number: 112362-50-2
CAS Name: (26
R,27
S)-26-[[2-(Diethylamino)ethyl]sulfonyl]-26,27-dihydrovirginiamycin M1
Synonyms: 26-(2-diethylaminoethyl)sulfonylpristinamycin IIB
Manufacturers' Codes: RP-54476
Molecular Formula: C34H50N4O9S
Molecular Weight: 690.85
Percent Composition: C 59.11%, H 7.29%, N 8.11%, O 20.84%, S 4.64%
Literature References: Semisynthetic polyunsaturated macrolactone type II streptogramin,
q.v. Prepn: J.-C. Barriere
et al., EP 191662;
eidem, US 4668669 (1986, 1987 both to Rhone-Poulenc).
In vitro activity: H. C. Neu
et al., J. Antimicrob. Chemother. 30, Suppl. A, 83 (1992). HPLC determn in plasma: A. Le Liboux
et al., J. Chromatogr. B 708, 161 (1998)
Properties: White solid, mp ~150°.
Melting point: mp ~150°
Derivative Type: Mixture with quinupristin
CAS Registry Number: 126602-89-9
Manufacturers' Codes: RP-59500
Trademarks: Synercid (Rh>e-Poulenc)
Literature References: Semisynthetic streptogramin comprised of two synergistic components in a defined 70:30 percent w/w mixture of dalfopristin and quinupristin,
q.v., mesylate salts. HPLC determn for quality control: B. Vasselle
et al., J. Pharm. Biomed. Anal. 19, 641 (1999).
In vitro activity in comparison with pristinamycin,
q.v.: A. Lozniewski
et al., Pathol. Biol. 48, 463 (2000). Clinical trial in vancomycin resistant
Enterococcus faecium (VREF) infection: R. C. Moellering
et al., J. Antimicrob. Chemother. 44, 251 (1999); in skin infections: R. L. Nichols
et al., ibid. 263.
Review: B. Pavan,
Curr. Opin. Invest. Drugs 1, 173-180 (2000).
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics).