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CAS No 110690-43-2 , (6-benzoyloxy-3-cyanopyridin-2-yl)
3-[3-(ethoxymethyl)-5-fluoro-2,6-dioxopyrimidine-1-carbonyl]benzoate

  • Name: (6-benzoyloxy-3-cyanopyridin-2-yl)
    3-[3-(ethoxymethyl)-5-fluoro-2,6-dioxopyrimidine-1-carbonyl]benzoate
  • Synonyms: 110690-43-2; Bof A2;(6-benzoyloxy-3-cyanopyridin-2-yl)
    3-[3-(ethoxymethyl)-5-fluoro-2,6-dioxopyrimidine-1-carbonyl]benzoate; CCRIS 6984;BOF-A2;
  • CAS Registry Number:
  • Density: 1.52 g/cm3
  • Refractive index: 1.663
  • Safety Statements: A poison by ingestion and subcutaneous routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic vapors of NOx and F−.
  • Hazard Symbols: A poison by ingestion. A reproductive hazard.
  • Molecular Weight: 558.470863
  • InchiKey: WTSKMKRYHATLLL-UHFFFAOYSA-N
  • InChI: InChI=1S/C28H19FN4O8/c1-2-39-16-32-15-21(29)25(35)33(28(32)38)24(34)18-
    9-6-10-19(13-18)27(37)41-23-20(14-30)11-12-22(31-23)40-26(36)17-7-4-3-5-
    8-17/h3-13,15H,2,16H2,1H3
  • Molecular Formula: C28H19FN4O8
  • Molecular Structure:CAS No:110690-43-2 (6-benzoyloxy-3-cyanopyridin-2-yl)<br />3-[3-(ethoxymethyl)-5-fluoro-2,6-dioxopyrimidine-1-carbonyl]benzoate

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110690-43-2 Emitefur

  • Emitefur
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110690-43-2 Benzoic acid,3-[[3-(ethoxymethyl)-5-fluoro-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl]carbonyl]-,6-(benzoyloxy)-3-cyano-2-pyridinyl ester

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110690-43-2 Emitefur

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110690-43-2 Emitefur

  • Emitefur, Min 99%
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110690-43-2 Emitefur

  • Emitefur, 99%
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110690-43-2 EMITEFUR

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References of (6-benzoyloxy-3-cyanopyridin-2-yl)
3-[3-(ethoxymethyl)-5-fluoro-2,6-dioxopyrimidine-1-carbonyl]benzoate
Title: Emitefur
CAS Registry Number: 110690-43-2
CAS Name: 3-[[3-(Ethoxymethyl)-5-fluoro-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl]carbonyl]benzoic acid 6-(benzoyloxy)-3-cyano-2-pyridinyl ester
Synonyms: 3-[3-(6-benzoyloxy-3-cyano-2-pyridyloxycarbonyl)benzoyl]-1-(ethoxymethyl)-5-fluorouracil
Manufacturers' Codes: BOF-A2
Molecular Formula: C28H19FN4O8
Molecular Weight: 558.47
Percent Composition: C 60.22%, H 3.43%, F 3.40%, N 10.03%, O 22.92%
Literature References: Bifunctional prodrug composed of a derivative of 5-fluorouracil (5-FU) and 3-cyano-2,6-dihydroxypyridine (CNDP), an inhibitor of 5-FU degradation by dihydrouracil dehydrogenase. Prepn: S. Fujii, DE 3709699; idem, US 4983609 (1988, 1991 both to Otsuka); M. Hirohashi et al., Chem. Pharm. Bull. 41, 1498 (1993). Antitumor activity: S. Fujii et al., Jpn. J. Cancer Res. 80, 173 (1989). Mechanism of action: T. Okayasu et al., ibid. 85, 101 (1994). Clinical evaluation in lung cancer: Y. Nakai et al., Acta Oncol. 33, 523 (1994). Toxicity study: H. Kinoshita et al., Yakuri to Chiryo 22, 81 (1994), C.A. 121, 99197 (1994).
Properties: Crystals, mp 162-164°. LD50 in mice, male rats, female rats (mg/kg): >5000, 1850, 1934 orally (Kiroshita).
Melting point: mp 162-164°
Toxicity data: LD50 in mice, male rats, female rats (mg/kg): >5000, 1850, 1934 orally (Kiroshita)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Antimetabolites; Pyrimidine Analogs.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.